Leaders in BioBanking Congress 2015 - 2015生物数据库学会 -
2015年7月14 - 16日
加拿大,安大略省,多伦多,多伦多中心洲际酒店

目前生物检体的采集由各种研究团体所进行,其目的亦包括从基础研究到临床实验。对高品质的生物学研究而言,完善管理的生物数据库是不可或缺的。此外,适当的生物检体采样、处理、保存及追踪,为研究人员以更佳形式结合分子信息与临床信息上非常重要的因素。因此,生物数据库可说是与科学及商业双方面息息相关。

Cambridge Healthtech Institute (CHI)举办的第7届International Leaders in Biobanking Congress: Maximizing Your Investment in Biospecimens,为聚焦生物数据库在科学及商业两个层面的学会。会期中将邀集生物医学和生物医药品的研究人员、法规当局、生物检体入出库管理者及实务人员等,探讨在现今最尖端研究的生物医学研究上如何有效利用生物检体的最佳策略。


会前短期课程 | 第1天 | 第2天 | 第3天 | 会后会 | 演讲者


7月13日(一)

1:00 pm 短期课程报到登记


1:30-5:30 会前短期课程*

* 敬请个别报名参加


5:00 主会议报到登记


研究设施实地考察与交流晚会:University Health Network (UHN)的生物检体研究计画

(参加人数以50名为限)

6:00-8:00

5:45 搭乘研究设施实地考察接驳车

* 免费提供往返Intercontinental Toronto Centre与研究设施的接驳车服务。

6:00-8:00 实地考察与交流晚会:UHN的生物检体研究计画

This tour at Canada's largest academic hospital system begins in surgical pathology with the banking of complex surgical specimens and data entry into our customized caTissueSuite research specimen management system. The tour continues to our laboratories for a demonstration of our state-of-the-art biospecimen information technology system, digital image analysis and laser capture microdissection.

8:00 搭乘接驳车返回饭店

8:15 会前短期课程结束


会前短期课程 | 第1天 | 第2天 | 第3天 | 会后会 | 演讲者


7:30 am 7月14日(二)

7:30 am 主会议报到登记与晨间咖啡


专题讲习:做为社区整体所必须的作为

8:00 欢迎致词与议长开会引言

Michael RoehrlMichael H. A. Roehrl, M.D., Ph.D., Director, UHN Program in BioSpecimen Sciences, University Health Network and University of Toronto

8:15 病理学者做为生物检体管理者所承担责任的复杂度

Sylvia AsaSylvia L. Asa, M.D., Ph.D., Pathologist-in-Chief, Medical Director, Laboratory Medicine Program, University Health Network; Lakeridge Health & Women's College Hospital; Senior Scientist, Ontario Cancer Institute; Professor, Laboratory Medicine & Pathobiology, University of Toronto

Pathologists have responsibility for handling patient biospecimens; they implement rigorous quality assurance of processes that determine how specimens are collected, processed, examined, reported and either destroyed, biobanked or retained on file. Pathology is ideally positioned to develop and oversee biobanks and because of its capacity for data generation, generally provides the greatest amount of information for specimen annotation. Pathology also is subject to mandatory requirements for retention of clinical records, including tissue blocks and slides, for legal and accreditation purposes, emphasizing the importance of collecting and documenting biospecimens for research.

9:00 使用与电子健康纪录(EHR)连动的生物数据库之发现与执行:eMERGE的经验

Rex ChisholmRex L. Chisholm, Ph.D., Vice Dean, Scientific Affairs and Graduate Education; Adam and Richard T. Lind Professor, Medical Genetics, Northwestern University Feinberg School of Medicine

Biobanks linked to electronic health records (EHR) provide a unique opportunity to study the association between genetic variation and phenotypes. The eMERGE network, funded by the National Human Genome Research Institute, has not only demonstrated the utility of this approach, but has also begun to develop methods for associating specific genomic variants with EHRs and providing clinical decision support to assist care providers in the use of this information.

9:45 休息时间

10:15 未来使用之研究样品的制备:因应功能性品质管理评价的创新手法与生物数据库的最佳实务

Andrew BrooksAndrew Brooks, Ph.D., COO, RUCDR Infinite Biologics; Associate Professor, Genetics, Rutgers University

The presentation focuses on biomarker development and translational research optimization by taking into account how samples are collected, selection of the best technology for sample bioprocessing, global biobanking best practices and how information on each sample should be stored to enhance data sharing throughout the research process. Specific topics to be discussed include:

  • Sample bioprocessing and quality control methods that maximize the utility of collected biospecimens for current and future research
  • Understanding the power of evolving genomic technologies and how to develop a sample-centric roadmap for future research use
  • The role of centralized biobanking and global data integration in real-time data mining and optimization of biospecimen resources
  • How to build scientific and operational biomarker development synergies through collaborations to increase research productivity

11:00 生物检体入出库网络的综合标准作业程序的制定-CTRNet的经验

Brent SchacterBrent Schacter, M.D., FRCPC, Principal Investigator, CTRNet; Professor, Department of Internal Medicine, Section of Hematology/Oncology, College of Medicine, University of Manitoba/CancerCare Manitoba

The Canadian Tissue Repository Network is a consortium of Canadian tumour biorepositories that aims to enhance biobanking capacity and quality through standardization. To minimize the issue of variable biobanking practices, CTRNet has developed and maintained a comprehensive set of standard operating procedures (SOPs). The key elements of the CTRNet SOP development process will be described. Once developed, reviewed and ratified by CTRNet, the SOPs have been published on our website for public access (with over 15,000 downloads in over 60 countries).

11:45 讲习结束

12:00 pm 午餐会简报(赞助商招募中)或各自享用午餐


高品质生物数据库的维持

2:00 议长引言

Andrew BrooksAndrew Brooks, Ph.D., COO, RUCDR Infinite Biologics; Associate Professor, Genetics, Rutgers University

2:05 社区医院系统的全国生物检体采集网络之建立与执行

Jeffrey OttoJeffrey Otto, MBA, Ph.D., National Director, Center for Translational Research, Institute for Research and Innovation, Catholic Health Initiatives

Catholic Health Initiatives is the fifth-largest health system in the U.S., with 100+ hospitals spread nationally. Within this community hospital system, the Center for Translational Research (CTR) has built a first-of-its-kind hub-and-spoke biorepository program. Key attributes of this biorepository include: 1) high physical biospecimen quality, 2) EMR-linked patient data, and 3) full chain of custody. This presentation discusses how this program was built.

2:35 库存管理:生物检体入出库的重整、整理统合、品质确保、空间成本

Sherilyn SawyerSherilyn J. Sawyer, Ph.D., Director, BWH/Harvard Cohorts Biorepository, Channing Division of Network Medicine, Brigham and Women's Hospital

Space and organization within the available space are two high-level concerns of the biorepository. We have recently undertaken a multiyear project to reorganize inventory in order to recover lost space and utilize space more efficiently. A cost/benefit analysis of this project contributes to understanding the true costs of space for biorepositories.

3:05 赞助商简报

Speaker to be Announced

3:20 赞助商简报

3:35 展示会场休息与论文海报鉴赏

4:00 针对受试者同意的课题以及老旧生物数据库检体的再同意之Web型解决方案

Daniel ThielDaniel B. Thiel, Public Health Researcher, Health Services Organization and Policy, University of Michigan School of Public Health

Highlighting the results of a pilot web-based informed consent portal for legacy donors to the Michigan BioTrust for Health, this presentation explores practical and ethical challenges raised by informed consent for legacy donors to biobanks. In the case of Michigan's BioTrust, the legacy samples are residual dried bloodspots derived from state-mandated newborn screening. I also consider this experiment in light of broader implications for biobanks comprising legacy samples.

4:30 组织库、生物信息学、电子病历系统(EMR):个性化医疗的前提条件

K. Stephen SuhK. Stephen Suh, Ph.D., Director, Genomics and Biomarkers Program, John Theurer Cancer Center, Hackensack University Medical Center

Personalized medicine promises patient-tailored treatments that enhance patient care and decrease overall treatment costs by focusing on genetics and "-omics" data obtained from patient biospecimens and records to guide therapy choices that generate good clinical outcomes. The approach relies on diagnostic and prognostic use of novel biomarkers discovered through combinations of tissue banking, bioinformatics and electronic medical records (EMRs).

5:00 座谈会:透过有效使用以确保生物数据库的价值

Biobanks are necessary and expensive research infrastructures. The ability to demonstrate effective utilization of biobanks is a quality measure that is essential for both financial and social sustainability. This panel discusses approaches for effective utilization of specimens from biobanks, both in the establishment of new biobanks and in the use of legacy collections.

Moderators:

Marianne-HendersonMarianne K. Henderson, MS, CPC, Chief, Division of Cancer Epidemiology & Genetics, Office of Division Operations and Analysis and the Center for Global Health, National Cancer Institute; Chair, Organizing Advisory Committee, ISBER



Marianna BledsoeMarianna J. Bledsoe, MA, Adjunct Assistant Professor, Department of Clinical Research and Leadership, George Washington University School of Medicine and Health Sciences; Co-Chair, Science Policy Committee, ISBER

Panelists:

Jeffrey OttoJeffrey Otto, MBA, Ph.D., National Director, Center for Translational Research, Institute for Research and Innovation, Catholic Health Initiatives

Sherilyn SawyerSherilyn J. Sawyer, Ph.D., Director, BWH/Harvard Cohorts Biorepository, Channing Division of Network Medicine, Brigham and Women's Hospital

K. Stephen SuhK. Stephen Suh, Ph.D., Director, Genomics and Biomarkers Program, John Theurer Cancer Center, Hackensack University Medical Center

Daniel ThielDaniel B. Thiel, Public Health Researcher, Health Services Organization and Policy, University of Michigan School of Public Health

Additional Panelists to be Announced

6:00 展示会场欢迎晚会与论文海报鉴赏

7:00 第1天结束


会前短期课程 | 第1天 | 第2天 | 第3天 | 会后会 | 演讲者


7月15日(三)

7:30 am 早餐会简报(赞助商招募中)或晨间咖啡

8:00 生物数据库脑力激荡:为早餐会小组讨论

咖啡小组讨论。本讨论会是以参加者交换意见、探讨问题解决对策的形式进行,来自不同背景的参加者针对焦点议题发表各自的想法和经验,并发展未来的合作关系。

品质系统-生物数据库所有要素所依据的脉络

Michael BreardMichael Breard, MS, MT(ASCP)SBB, CQA(ASQ), PMP(PMI), Vice President, Consulting Services and Sale, AABB

  • What is a quality system?
  • Why is quality important?
  • How do you achieve quality?
  • Is quality expensive?
  • What does it take to reach your quality goal?

Inventory Management and Data Annotation

Rajiv Dhir, M.D., MBA, Chief, Pathology, Shadyside Hospital, University of Pittsburgh Health Systems

  • What is inventory management and how do you currently address your needs?
  • What are the most common problems you have with inventory management?
  • What are the most common data annotation needs seen by you and how do you address them?
  • How do you provide data to your clients/investigators? Do you utilize honest brokers?

生物检体、生物标记、临床试验

9:00 议长引言

Jeffrey OttoJeffrey Otto, MBA, Ph.D., National Director, Center for Translational Research, Institute for Research and Innovation, Catholic Health Initiatives

9:05 特别演讲:透过临床试验将精确医疗策略转化成结果

Lillian SiuLillian L. Siu, M.D., FRCPC, Professor, University of Toronto; Medical Oncologist, Princess Margaret Cancer Centre

Clinical trial frameworks focusing on interpatient heterogeneity include histology-based trials to evaluate therapeutic targeting of different molecular aberrations harbored by patients with a single tumor type ("umbrella trials"); as well as those that are histology-agnostic, aberrationspecific to encompass the assessment of similar molecular changes across different tumor types ("basket trials"). In this presentation, the benefits and challenges of genomics-based clinical trials are discussed, including a forecast into the next-generation precision medicine-based clinical research.


9:35 多中心型淋巴瘤临床试验的相关研究上的生物检体调度

Koren MannKoren Mann, Ph.D., Assistant Professor, Oncology, Lady Davis Institute for Medical Research, McGill University

To develop novel agents in lymphoma, we must understand the molecular changes induced by these drugs, particularly in the context of clinical trials. We have developed a series of standard operating procedures (SOPs) to collect quality biospecimens for multiple downstream applications, including immunohistochemistry, exome sequencing, gene expression profiling, metabolomics and circulating tumor DNA. These SOPs were then validated in the context of the Q-CROC2 trial testing the efficacy of the histone deacetylase inhibitor, panobinostat, +/- rituximab in diffuse large B-cell lymphoma.

10:05 赞助商简报

10:35 展示会场休息与论文海报鉴赏

11:15 个案研究#1:生物检体科学、临床试验、精确医疗:实务案例

Michael RoehrlMichael H. A. Roehrl, M.D., Ph.D., Director, UHN Program in BioSpecimen Sciences, University Health Network and University of Toronto

Anthony JoshuaAnthony M. Joshua, MBBS, Ph.D., Staff Oncologist/Affiliate Scientist, Princess Margaret Cancer Centre

We discuss the use of human biospecimens for translational research, in particular molecularly driven clinical trials and our Rapid Autopsy Program. We discuss optimal collection, use and quality of samples, patient enrollment and consent, and integrated clinical and research data collection and annotation.

12:00 pm 讲习结束

12:15 午餐会简报(赞助商招募中)或各自享用午餐


评价生物检体品质的手段

2:00 议长引言

Galen-HostetterGalen Hostetter, M.D., FCAP, Associate Director, Pathology Core, Van Andel Research Institute





2:05 从研究阶段到临床阶段:(前)解析变量与分析平台

Veronique NeumeisterVeronique Neumeister, M.D., Laboratory Director, Specialized Translational Services Lab, Department of Pathology, Yale University School of Medicine

Companion diagnostic tests are critically dependent on tissue quality. However, tissue handling and processing are not always tightly controlled and pre-analytical variables can significantly alter tissue quality. This presentation focuses on the effects of (pre-)analytical variables in the diagnostic and research setting. Methodology and importance of quality control, optimization and standardization of tissue processing, biomarker validation and development of useful laboratory tests for the clinical setting will be discussed.

2:30 成为人体生物数据库参考的实验动物模型

Galen-HostetterGalen Hostetter, M.D., FCAP, Associate Director, Pathology Core, Van Andel Research Institute

Experimental animal models have been widely used to inform veterinary and human pathophysiology with associated improved control of pre-analytic variables to include single marker QC probes or next-generation genomic sequencing of disaggregated tissue samples. We demonstrate animal experiments to combine tissue morphology and expressed protein by IHC, qualitative/quantitative measures of nucleic acids by RIN and Q-ratios, respectively, to assess effect of pre-analytic variables and provide the basis for standardized methods in tissue sample collection and processing.

2:55 加压冷冻:冷冻保存的新手法

Nickolas GreerNickolas Greer, CSO, Rissali LLC

Chemical cryoprotectants are toxic to live cells, tissues and organs. Cryoprotectant toxicity increases with concentration. Both hydraulic pressure and cryoprotectants increase viscosity of aqueous solutions at the freezing point, inhibit ice crystal growth and induce vitrification of water. By applying pressure during freezing it may be possible to reduce concentration or eliminate cryoprotectants for preservation of viable biological materials, thereby solving the cryoprotectant toxicity problem.

3:20 血液银行所使用变性加工解决方案以收集及保存红色细胞的微流体装置评价

Dana SpenceDana Spence, Ph.D., Associate Professor, Department of Chemistry, Michigan State University

The collection and storage solutions used to process erythrocytes for storage in transfusion medicine contain levels of glucose that are nearly 10-15x higher than that found in the circulation of a healthy human. Here, data is presented demonstrating that maintenance of normoglycemic levels during the blood storage process helps to maintain certain properties of the stored cells, even beyond five weeks in storage.

3:45 赞助商简报

4:15 展示会场休息与论文海报鉴赏


4:50 特别演讲:影响因应多设施共同研究下免疫监测的末梢血液样本的解析前变量

Amit Bar-OrAmit Bar-Or, M.D., FRCPC, Professor, Neurology & Neurosurgery; Director, Experimental Therapeutics Program and Scientific Director, Clinical Research Unit, Montreal Neurological Institute, McGill University

While there has been rapid growth in multicenter biomarker-development and immune-monitoring initiatives, including a major investment in procuring biological samples for cell-based assays, relatively little has been done to formally assess the impact of pre-analytical variables on functional immune responses within such samples. This presentation considers the impact of shipping approach and ambient temperature on such readouts.



个案研究:生物数据库与用户的合作

Biomedical researchers and drug developers require accessible, highquality biospecimens that allow them to extract reliable and useful data. Oncology experts, for instance, use patient-derived tumor collections to connect datasets, pinpoint and assess variants within cancer patients post-diagnosis and zero in on the data that matter when tailoring therapies. Early, strategic collaborations with the biobanks that house specimens can be mutually beneficial, maximizing the financial and technological investments of the operation managers who collect, store, annotate and distribute the biological samples ("biobankers") and supporting the research goals of the scientists who need those samples ("biousers") - all to fulfill the promise of personalized medicine.


5:15 个案研究#2

6:00 讲习结束

6:00 短期课程报到登记晚餐


6:15-9:30 短期课程*

* 敬请个别报名参加


会前短期课程 | 第1天 | 第2天 | 第3天 | 会后会 | 演讲者


7月16日(四)

7:30 am 早餐会简报(赞助商招募中)或晨间咖啡


锁定专门领域的生物数据库

8:00 议长引言

Marianna BledsoeMarianna J. Bledsoe, MA, Adjunct Assistant Professor, Department of Clinical Research and Leadership, George Washington University School of Medicine and Health Sciences; Co-Chair, Science Policy Committee, ISBER

8:05 iPS细胞生物数据库的未来

Jonathan Y.H. LohJonathan Y.H. Loh, Ph.D., Assistant Professor, Department of Biological Sciences, National University of Singapore, A*STAR Institute of Molecular and Cell Biology

We have developed the technology for efficient derivation of transgene-free hiPSCs from human finger-prick blood. Finger-prick sample collection can be performed on a "do-it-yourself" basis by donors and sent to the hiPSC facility for reprogramming. We show that single-drop volumes of finger-prick samples are sufficient for performing cellular reprogramming, DNA sequencing, and blood serotyping in parallel. Our novel strategy has the potential to facilitate the development of large-scale hiPSC banking worldwide.

8:35 以改善心脏移植结果为目的的生物数据库

Dawn BowlesDawn E. Bowles, Ph.D., Assistant Professor, Department of Surgery, Division of Surgical Sciences and Co-Director, Duke Human Heart Repository

A human cardiac transplant biorepository for research on improving cardiac transplantation outcomes has been established. Evidence indicates an association between the levels of cardiac injury biomarkers in the preservation/transportation fluid from the donor heart of transplant cases and the development of inadequate cardiac function post-implant in the recipient. Continued evaluation of the preservation fluid will lead to better understanding of preservation injury and optimization of preservation/transport solutions for cardiac transplant.

9:05 针对儿童与妇女的制度化医院的计画立案与执行:伦理面与经营面的课题

Suzanne VercauterenSuzanne Vercauteren, M.D., Ph.D., FRCPC, Head, Division of Hematopathology, BC Children's Hospital and Clinical Assistant Professor, Pathology and Laboratory Medicine, University of British Columbia

The BCCH BioBank's goal is to ethically collect biospecimens and clinical data from pediatric and adult patients with a range of conditions and store them systematically for future research. Its founding principles include public engagement, long-term sustainability and high-quality specimens. Its planning and implementation was a complex process that involved detailed consideration of the ethical issues concerning the different types of potential participants and careful consideration of the operational structure of the biobank.

9:35 赞助商简报

10:05 展示会场休息与论文海报鉴赏

10:45 University Health Network (UHN)的泌尿生殖器生物数据库

Neil FleshnerNeil Fleshner, M.D., MPH, FRCSC, Chair, Urology, Department of Surgery, University of Toronto; Head, Urology, University Health Network; Director, GU BioBank, Princess Margaret Cancer Centre

The GU (genitourinary) BioBank is a predominantly bio-fluid-based program that follows consenting GU oncology participants over time, obtaining additional specimens and data at predefined intervals and upon any change in clinical state. This capacity for frequent and long-term follow-up has been made possible by integrating the BioBanking process with clinical care at UHN. The GU BioBank has garnered an incredible amount of interest in recent years. We share our experience in setting up and maintaining this patient-centered research program.

11:15 个案研究#3(赞助商招募中)

12:00 pm 讲习结束

12:15 午餐会简报(赞助商招募中)或各自享用午餐


锁定专门领域的生物数据库(接续)

2:00 议长引言

Marianne-HendersonMarianne K. Henderson, MS, CPC, Chief, Division of Cancer Epidemiology & Genetics, Office of Division Operations and Analysis and the Center for Global Health, National Cancer Institute; Chair, Organizing Advisory Committee, ISBER



2:05 加拿大国立脐带血银行概要

Heidi ElmoazzenHeidi Elmoazzen, Ph.D., Director, National Public Cord Blood Bank

Canadian Blood Services is building a National Public Cord Blood Bank which consists of five collection sites in four cities: Ottawa, Brampton, Edmonton and Vancouver, as well as two manufacturing facilities in Ottawa and Edmonton. An overview of the sources and use of hematopoietic stem cells as well as an overview of cord blood processing, cryopreservation and storage will be provided.

2:35 多伦多肺脏移植生物数据库计画所采集的检体

Sassan AzadSassan M. Azad, Project Manager, Clinical, Translational & Biobanking Research Office, Toronto Lung Transplant Program, Toronto General Hospital, University Health Network

The Toronto Lung Transplant Program, one of the world's largest, is supporting clinical research in end-stage lung disease and advancing lung transplantation. Two major areas that limit successful application of lung transplantation are ischemia reperfusion injury (IRI) and bronchiolitis obliterans (BO). Our work explores underlying mechanisms of both these injuries and the development of therapeutic strategies to prevent or reverse them. Our current research focus is on biomarker discovery and gene therapy in lung transplantation.

3:05 休息时间,展示会与论文海报鉴赏的最后机会


利用IT以维持高品质的生物数据库

4:15 可扩展研究数据库的临床数据及生物检体入出库数据收集的进展

Maureen E. Lane, Ph.D., Assistant Professor, Medicine; Director, Hem/Onc Translational Core Laboratory, The Leukemia Biorepository and Personalized Medicine Center, Weill Cornell Medical College

The Leukemia group at Weill Cornell Medical Center has been working with our information technology services (ITS) group to develop a Research Data Repository (RDR) that marries relevant clinical data with samples from our AML biorepository. This project is one of three pilot projects with a focus on supporting Precision Medicine and translational research at Weill Cornell.

4:40 因应转译研究与基础研究的数据库与生物检体入出库

Annmarie NowakAnnmarie Nowak, Coordinator & Director, Data Bank and Biorepository, Biobanking Systems Integration Cancer Prevention and Population Science, Roswell Park Cancer Institute

The Data Bank and BioRepository (DBBR) at Roswell Park Cancer Institute is a comprehensive data and sample bank, with biospecimens, epidemiologic and clinical information for investigators conducting translational research related to cancer prevention, etiology, detection and treatment. We discuss our recruitment, procurement and processing procedures, the structure and function of LIMS and the integration of clinical, research and biospecimen data.

5:05 高品质生物数据库的实现与因应生物数据库品质提升的作为:CRIP ToolBox与元生物数据库架构p-BioSPRE

Christina SchröderChristina Schröder, Ph.D., Head, Metabiobanks CRIP, Fraunhofer Institute for Cell Therapy and Immunology

While biobank registries and catalogs will at best allow queries for specific biobank collections or cohorts, trans-institutional metabiobanks enable parameterized, stratified, though privacy-preserving queries in connected biobanks on a case-by-case and sample-by-sample basis. Building such metabiobanks for a decade, and drawing upon broad expertise in semantic data integration across sectors relevant for translational biomedical research, we have developed the metabiobank software suite "CRIP Toolbox". We showcase p-BioSPRE, the metabiobank setup for the EU FP 7-funded project p-medicine, as a multipurpose tool to internationally access and promote quality biobanks online.

5:30 学会结束


会前短期课程 | 第1天 | 第2天 | 第3天 | 会后会 | 演讲者


会后活动

7月17日(五)


因应生物数据库研究的受试者同意的内容与手续要件*

8:30 am-5:00 pm



This course presents the elements of the informed consent document and the components of the process, specifically as they relate to biobanking studies.

Instructor: Elizabeth Ronk Nelson, MPH, Barnett International


Participants will receive 7 hours (0.7 CEUs) from Accreditation Council for Pharmacy Education for full participation. For further information please visit barnettinternational.com

* 敬请个别报名参加



会前短期课程 | 第1天 | 第2天 | 第3天 | 会后会 | 演讲者

* 活动内容有可能不事先告知作更动及调整。

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