Discovery on Target 2016 海报标题

 

Company Title
Immune Biosolutions 3D-Specific Chicken Antibodies Targeting GPCR Extracellular Loops
DiscoverX Corporation A Duplexed Assay for Measurement of GPCR-Mediated Calcium Signaling and PathHunter® β-Arrestin Recruitment from Single Well Using FDSS/µ-Cell Functional Drug Screening System
BellBrook Labs A Homogenous, Universal Enzymatic Assay for Histone Methyltransferases Based on a Microbial Riboswitch
Cellular Technology Ltd. A Multi-Color Natural Killer-Cell Mediated Cytotoxicity Detection Using Fluorescence and Direct Cell Imaging
ZoBio BV A New Approach to Inhibiting Lysine Methyl Transferases
GVK Biosciences Pvt. Ltd. A Selective TrkA Inhibitor Displays Positive Cooperativity with ATP Competitive Trk Inhibitor and Is Efficacious in Multiple TrkA Driven Fusion Xenografts
Shanghai Jiao-Tong University Allosteric Inhibition of SIRT6 as Novel Therapeutic Strategy
Chinese University of Hong Kong Anergic Natural Killer Cells in Liver Cancer Patients: Ex Vivo Expansion and Activation
Hummingbird Bioscience Applying a Rational Antibody Development Platform to the Generation of Validated Therapeutic Antibodies for Gastric, Breast and Colorectal Cancer
BellBrook Labs Aptamer Based Homogenous Single-Reagent HTS Assay Platform for Human Growth Factors
Structural Genomics Consortium Assay Development and Inhibitor Screening for Ubiquitin-Specific Protease Complexes
University of Illinois at Chicago Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease
Promega Corporation Bioluminescent Cell-Based Assays: Monitoring LDLR and PCSK9 Interaction and Changes in LDL Uptake
Dynamic Biosensors GmbH Biophysical Analysis of Cas9 - DNA Interactions and Enzymatic Activity with the switchSENSE Biosensor Platform
Collaborative Drug Discovery CDD Vault: A Hosted Biological and Chemical Database to Securely Manage Private and External Data
Netherlands Translational Research Center BV Comparative Cancer Cell Line Profiling Differentiates the Mechanism of Action of Different EZH2, PI3K/mTOR, and Aurora Kinase Inhibitors
Medivir AB Comprehensive Profiling of DUBs Inhibitors Using the Medivir DUB Platform
Cellecta, Inc. CRISPR/Cas9 Genome-Wide gRNA Library for Target Identification
Dharmacon, part of GE Healthcare CRISPR-Cas9 Genome Engineering Utilizing Chemically Synthesized RNA
Integral Molecular Deorphaning, Specificity Profiling and Epitope Mapping of MAbs Targeting Membrane Proteins
University of Hong Kong Design and Synthesis of Pan-Bromodomain Probe
Promega Corporation Detection of JumonjiC Domain-Containing Histone Demethylase Activities with a Homogeneous Bioluminescent Succinate Assay
BellBrook Labs Determination of Drug Residence Times in a HTS Format Using Transcreener ADP[2] Kinase Assay
Ehime University Development of a Novel NF-κB Inhibitor
ConverGene LLC Development of Dual - Activity Small Molecules that Target BRD4 and Dopamine Receptor D2
Korea Institute of Science and Technology Development of Novel S1P1 and S1P5 Receptor Agonist for Treatment of Multiple Sclerosis
Virginia Commonwealth University Development of Peptide-SAM Conjugates as Potent and Specific Probes for Protein Methyltransferase
University of Louisville Differences in Human Meibum Composition with Age, Meibomian Gland Dysfunction and After Treatment with Azithromycin and Doxycycline Using 1H NMR Spectroscopy
Integral Molecular Discovery of New Therapeutics to Challenging GPCRs, Ion Channels and Transporters
University of Texas MD Anderson Cancer Center Discovery of Novel Skp2-SCF Complex Inhibitors and Their Corresponding SAR and Molecular Dynamics Simulations
Abcam, Inc. Discovery of scFvs Against Mammalian Cell Membrane Target Proteins and Their Rapid Conversion to IgG and Generation of Stable Pools
Vanderbilt University Discovery of WDR5-MLL1 Inhibitors Using Fragment-Based Method and Structure-Based Design
Fox Chase Cancer Center Dual Inhibition of AKT and KIT is Synergistic in Gastrointestinal Stromal Tumor
PerkinElmer, Inc. Expanding the Toolbox of Gamma-Irradiated Frozen Cells Validated for GPCR-Mediated Kinase Signaling
Dharmacon, part of GE Healthcare Experimental Design Considerations for Homology-Directed Repair Utilizing a CRISPR-Cas9 System with Synthetic crRNA and tracrRNA
Life Chemicals, Inc. Fragment Screening Libraries
Sygnature Discovery Fragment-Based Hit Discovery for the Epigenetic Target, BRD3
Avacta Life Sciences Generation and Formatting of Affimer® Biotherapeutics for the Inhibition of the PD-L1/PD-1 Pathway
ModiQuest Research Generation of Functional Antibodies Against Transmembrane Tumor Targets
UCB Pharma Generation of Monoclonal Antibodies to Cell Membrane Targets Using UCB's Core Discovery Platform
Applied StemCell Genome Editing in Human iPSCs with CRISPR and TARGATT™ to Generate Advanced Cellular Disease Models
Cellecta, Inc. Genome-Wide Expression Profiling for Pathway Analysis and Biomarker Discovery
Active Motif High-Throughput Screening of the Hypoxia Pathway: Examining Promoter Response and Function
Abcam, Inc. High-Throughput, Purification-Free, Multiplexed Profiling of Circulating miRNA for Discovery, Validation, and Diagnostics
HP, Inc. HP Inkjet for Drug Interaction Studies and qPCR Reactions
Crystal Bioscience Human Sequence Antibodies from Transgenic Chickens
Ajou University Identification of Signaling Networks of HDAC6-CSE in HEK293 Cell and Human Aortic Endothelial Cell
Toxikon Corporation Image Analysis in Laser-Induced Choroidal Neovascularization (CNV) Model in Rats
DiscoverX Corporation InCELL Pulse™: A Novel Cellular Target Engagement Assay Platform for Drug Discovery
Al-Azhar University Induced Pluripotent Stem Cell Therapy in Retinitis pigmentosa
Dana-Farber Cancer Institute Inhibition of USP10 Induces Degradation of Oncogenic FLT3: A Novel Approach to Therapy of Leukemia
BellBrook Labs Interrogation of Modulators of GPCR and Small GTPase Activity: Screening GAPs and GEFs with the Transcreener® GDP Assay
University of Zurich Knowledge-Based Design of a Biosensor for Quantification of ERK Activation in Living Cells
University of Missouri Leveraging BET Inhibitor ARV-825 for Targeting Human and Dog Transitional Cell Carcinoma: A One Health One Medicine Approach
Avacta Life Sciences Linkage-Specific, Affimer-Based Tools for the Study of Atypical Ubiquitin Chains
Desktop Genetics Ltd. Making the Cut: Software for Designing a Revolution in Gene Editing
Dartmouth College Mechanisms of Resistance to Proteasome Inhibitors in Multiple Myeloma
Eastern Virginia Medical School Metabolites, Lipids, N-Glycans, and Histology on the Same Biopsy
Caprion Biosciences, Inc. Metaproteomic Analysis of the Infant Fecal Microbiome
University of Michigan Microvesicle-Mediated Delivery of Transmembrane Protein to Rabbit Cornea
Ehime University Monoclonal Antibody Development Against GPCRs Using Cell-Free Synthesized Antigens
Abcam, Inc. Multiplex Immunoassays Done Differently: Lower Sample Requirement, Broader Dynamic Range and Increased Flexibility
TTP Labtech Ltd. Multiplexed Cell and Bead Based Assays in a No Wash Format for Biologics Screening and Characterisation
Queen's University Belfast Natural Killer-Like Signature Observed Post Therapy in Locally Advanced Rectal Cancer is a Determinant of Pathological Response and Improved Survival
Promega Corporation New Approaches for High Sensitivity Monitoring of Cellular Energy Metabolism
AssayQuant Technologies, Inc. Next Generation Sox-Based Substrate Sensors for Continuous, Homogeneous and Quantitative Monitoring of Protein Kinase Activity
PerkinElmer, Inc. Novel Bromodomain and Extra Terminal Domain (BET) Family Bromodomain Assays Utilizing AlphaLISA® and LANCE® Ultra (TR-FRET) Technologies
Daegu-Gyeongbuk Medical Innovation Foundation Novel Pin1 Inhibitor Induces Apoptosis in Breast Cancer
Nuevolution A/S NUE7770 - A BET-BD1 Selective Chemical Probe with Potent Cellular and In Vivo Anti-Inflammatory Activity
ONO Pharmaceutical Co., Ltd. ONO-0476: G Protein-Biased EP2 Receptor Agonist
Yale University Parathyroid Hormone Shows Novel Calcium Sensing Ability in Binding to Parathyroid Hormone 1 Receptor
Virginia Commonwealth University Photoaffinity Probes for Protein N-Terminal Methyltransferase
Life Chemicals, Inc. PPI and Epigenetic Targeted Libraries from Life Chemicals
Life Chemicals, Inc. PPI Inhibitor Screening Compound Libraries
Promega Corporation Profiling Small Molecule Kinase Inhibitors Using Bioluminescent Kinase Profiling Systems
Korea Basic Science Institute Proteomic and Bioinformatic Analysis of the Role of Cyp4a in the Liver of Type 2 Diabetic Mice
Oslo University Hospital Recombinant Enzymes Improve Homology Directed Repair of Cas9-Induced dsDNA Breaks
Active Motif Recombinant Protein Production Platform for Generation of High Quality Proteins to Use in the Development of Robust Assays for Epigenetic Drug Discovery
Molecular Medicine Research Institute Regulation of Skin Inflammation by Allosteric Modulation of the Adenosine A2A Receptor
PerkinElmer, Inc. Simultaneous Detection of Total and Phosphorylated Protein in Cellular Kinase Assays Using Alpha SureFire® Ultra™ Multiplex Technology
DiscoverX Corporation Specifically Measure Target Cell Death in a Co-Culture with Immune Cells Through a Non-Radioactive, Dye-Free Cytotoxicity Assay
GenScript USA Targeting Immune-Checkpoint Blockade by Single Domain Antibodies (sdAbs)
National Health Research Institutes Targeting KDM4A and Mitochondria Metabolism in Prostate Cancer
Academia Sinica The Deubiquitinating Enzyme USP37 Regulates the Oncogenic Fusion Protein PLZF/RARA Stability
University of Pennsylvania The Water-Solubilization of Membrane Proteins (wsMP) Algorithm: A Novel Computational Tool for GPCR-Based Drug Discovery
GlaxoSmithKline Therapeutic Potential of PRMT5 Inhibition in Breast Cancer
Merck Research Laboratories Towards a Platform for Studying Conformational Dynamics of Membrane Proteins Using Hydrogen-Deuterium Exchange Mass Spectrometry
Hiroshima University Ultra-Sensitive Regulation of the Nucleosome Binding of FACT, a Chromatin Remodeler, Through Multiple Phosphorylation to Its Intrinsically Disordered Regions (IDRs)

 

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