Cambridge Healthtech Institute's Fifth Annual

Enhancing Antibody Binding and Specificity

( 抗体结合与专一性强化 )

Scientific Strategies for Engineering Biotherapeutic Binding and Specificity for Next-Generation Antibody Therapeutics

2018年1月9日 - 10日

 

As the industry expands its repertoire of antibody drug products into new therapeutic areas, product formats and protein constructs, the control of antibody/antigen targeting, binding and specificity will take on a new level of importance for researchers in this field. The second meeting in the Peptalk Protein Engineering & Development pipeline, Cambridge Healthtech Institute's Fifth Annual Enhancing Antibody Binding and Specificity, presents innovative approaches to the modulation of binding activity for traditional antibodies, new product formats and difficult targets such as transmembrane proteins.

We invite presentation proposals on the following preliminary topics:

  • Binding to difficult targets (difficult epitopes, sugars, transmembrane proteins)
  • Conditionally binding antibodies
  • Correlating modeling and experimentation in studies of antibody binding/specificity
  • Improving selectivity, efficacy and safety for next-generation CAR-T cells
  • In silico modeling to support epitope mapping
  • Measuring and controlling polyspecificity and off-target binding for ADCs
  • Modification of site-specific ligation chemistry
  • Modulation of affinity to improve selectivity
  • Molecular dynamics simulations
  • Pretargeting to improve antibody specificity
  • Profiling antigen specificity
  • Targeting the tumor microenvironment

* 活动内容有可能不事先告知作更动及调整。