Cambridge Healthtech Institute's Seventh Annual

Higher-Throughput Protein Production and Characterization

( 高通量蛋白质制造与特性评估 )

Innovating Processes

2018年1月11日 - 12日

 

High-throughput processes have come of age by transforming the traditional protein-by-protein trial-and-error approach for testing criteria and scaling up. In this leading conference, HTP will be explored in the quest to develop methods that ensure quality and translate to large scale. Automation, robotics and liquid handlers will be discussed, along with developing small-scale models that shed light on bioproduction. Case studies will be presented that illustrate how leaders in the field are integrating HTP approaches to reduce the time and effort needed to successfully analyze proteins, fine tune processes, and achieve well-folded, pure protein.

Preliminary Agenda


HTP Purification and Production

Mitigating Developability Risks by Application of Affinity-Capture Self-Interaction Nanoparticle Spectroscopy (AC-SINS)

Craig D. Dickinson, Ph.D., Senior Research Advisor, AME, Eli Lilly and Company

Integrated High-Throughput Purification Platforms for Bio-Therapeutics R&D

Allan Matte, Ph.D., Senior Research Officer, Human Health Therapeutics, National Research Council Canada (NRC-CNRC)

High-Throughput Protein Production within the Swedish Human Protein Atlas Project

Hanna Tegel, Ph.D., Group Manager, Biotechnology, Proteomics and Nanobiotechnology, KTH Royal Institute of Technology


Using HTP to Develop and Produce Antibodies

Higher-Throughput Generation of Multi-Specific Antibody Therapeutics Including In Silico Design, Bulk Modular Cloning Procedures, and Automated Deconvolution of Variant Libraries
Joerg Birkenfeld, Ph.D., Section Head, High Throughput Biologics, R&D Biologics Research/Protein Therapeutics, Sanofi-Aventis Deutschland GmbH

High-Throughput Production of Antibodies Using Yeast and Mammalian Cells

Juergen Nett, Ph.D., Director, High Throughput Expression, Adimab, LLC

High-Quality Antibodies Targeting Protein Post-Translational Modification Sites through Affinity and Specificity Engineering

Yongku Cho, Ph.D., Assistant Professor, Chemical and Biomolecular Engineering, University of Connecticut


HTP Technologies to Analyze and Improve Processes

Flow Cytometry - An Old Dog with New Tricks for Ultra-High Throughput Screening of Recombinant Protein Libraries

Karl E. Griswold, Ph.D., Associate Professor, Thayer School of Engineering, Biological Sciences & Chemistry, Dartmouth College

High-Throughput Automations and Optimizations for Improved Binder Generation and Validation

Jonas V. Schaefer, Ph.D., Head, High-Throughput Binder Selection Facility, Biochemistry, University of Zurich

High-Throughput Methods for Protein Stability Prediction and Formulation Challenges Identification

Smita Raghava, Ph.D., Senior Scientist, Sterile Formulation Sciences, Merck & Co.


* 活动内容有可能不事先告知作更动及调整。