Cambridge Healthtech Institute's Ninth Annual

Protein Aggregation and Emerging Analytical Tools

( 蛋白质凝聚及新分析工具 )

Mechanism, Prediction, Screening, Immunogenicity and Formulation Challenges

2018年1月11日 - 12日

 

The popular Protein Aggregation and Emerging Analytical Tools conference covers latest trends, challenges and solutions in understanding, characterization and mitigation of problems generated by protein aggregation in biopharmaceuticals. This conference will feature in-depth case studies, new and unpublished data and interactive discussions on mechanisms of aggregation, new tools for detection and quantitation of aggregates, and how the data is used in regulatory filings. It will also discuss mechanistic understanding of protein aggregation and present case studies on prevention of particle formation by engineering and formulation approaches, aggregation in ADCs, bipecifics, impact of aggregation on production, aggregates as a factor for immunogenicity, and approaches for improvement of biophysical properties of protein solutions. We are looking for cutting edge research findings and unpublished data to be featured at this forum.

We invite you to present a poster and attend to join with colleagues from around the world in this discussion of the key challenges and solutions in protein aggregation in biotherapeutics.

Preliminary Agenda


IMMUNOGENICITY AND PROTEIN INSTABILITY

Immunogenicity of Protein Therapeutics

Yatin Gokarn, Ph.D., Head, Global Pharmaceutical Development Biologics, Sanofi Genzyme

Understanding Mechanism of Interaction Between E&L and Proteins Stability

Heather Flores, Scientist, Late Stage Pharmaceutical Development, Genentech, Inc.


MECHANISM, PREDICTION AND OVERCOMING PROTEIN AGGREGATION

Protein Solvation: Preventing Aggregation by Forming a Tighter 'Shield' around a Protein

Tom Laue, Ph.D., Professor Emeritus, Molecular, Cellular and Biomedical Sciences, University of New Hampshire

Characterizing and Inhibiting Glucagon Fibrillation

Elizabeth M. Topp, Ph.D., Dane O. Kildsig Chair and Department Head, Department of Industrial and Physical Pharmacy, Perdue University

Light-Induced Protein Disulfide Degradation: Product Characterization

Christian Schoneich, Ph.D., Distinguished Professor and Chair, Pharmaceutical Chemistry, University of Kansas


FORMULATION, PROCESS AND MANUFACTURING STRATEGIES

Formulation, Process and Manufacturing Strategies to Prevent and Overcome Aggregation Challenges in Early and Late Stage Development

Sreedhara Alavattam, Ph.D., Principal Scientist and Senior Group Leader, Genentech

Combining Protein-Protein Interaction Parameters to Correlate and Assess Protein Aggregation During Early Stage Formulation Development

Wei Qi, Ph.D., Scientist, Pre-Pivotal Drug Product, Amgen


NEW TOOL AND STRATEGIES FOR HTS SCREENING

Advances in High-Throughput Light Scattering for Developability and Early-Stage Biotherapeutic Formulation Studies

Sophia Kenrick, Ph.D., Senior Applications Scientist, Wyatt Technology


Talk Title to be Announced

Bernardo Cordovez, President, Halo Labs



AGGREGATION AND VISCOSITY CHALLENGES IN FILL FINISH PROCESSES

Particulate Formation During Fill & Finish Operations

Cheng Her, Ph.D., Postdoctoral Research Fellow, Carpenter Lab, Pharmaceutical Sciences, University of Colorado-Denver: Anschutz Medical Campus


* 活动内容有可能不事先告知作更动及调整。