Cambridge Healthtech Institute's Ninth Annual

Protein Aggregation and Emerging Analytical Tools

( 蛋白质凝聚及新分析工具 )

Mechanism, Prediction, Screening, Immunogenicity and Formulation Challenges

2018年1月11日 - 12日

 

The popular Protein Aggregation and Emerging Analytical Tools conference covers latest trends, challenges and solutions in understanding, characterization and mitigation of problems generated by protein aggregation in biopharmaceuticals. This conference will feature in-depth case studies, new and unpublished data and interactive discussions on mechanisms of aggregation, new tools for detection and quantitation of aggregates, and how the data is used in regulatory filings. It will also discuss mechanistic understanding of protein aggregation and present case studies on prevention of particle formation by engineering and formulation approaches, aggregation in ADCs, bispecifics, impact of aggregation on production, aggregates as a factor for immunogenicity, and approaches for improvement of biophysical properties of protein solutions. We are looking for cutting edge research findings and unpublished data to be featured at this forum.

We invite you to submit a proposal, present a poster and attend to join with colleagues from around the world in this discussion of the key challenges and solutions in protein aggregation in biotherapeutics.

We invite presentation proposals on the following preliminary topics:

  • Mechanistic understanding and prediction of protein aggregation especially for new therapeutic modalities, reversible protein aggregates, sub- micron particles
  • Immunogenicity of protein therapeutics: Aggregates as an inducing factor? Controlling adverse protein aggregation induction during patient handling and use
  • Protein aggregation in high concentration protein formulations
  • Preventive and analytical approaches for reduction and removal of aggregates
  • Design of aggregation resistant biotherapeutics: Ligand interactions that promote protein stability and prevent aggregation
  • Formulation, process and manufacturing strategies to prevent and overcome aggregation challenges in early and late stage development
  • Aggregation and viscosity challenges in fill finish processes: Protein aggregates clogging the filter, filter validation studies, ultrafiltration/diafiltration(UF/DF)
  • Rapid and high-throughput tools for prediction and measurement of aggregation, viscosity and solubility
  • New analytical tools: Development, qualification, and implementation analytical tools for studying protein structure and dynamics as related to aggregation
  • Detection and characterization of biological activity of protein aggregates in vivo

* 活动内容有可能不事先告知作更动及调整。