Cambridge Healthtech Institute's Tenth Annual

Protein Purification and Recovery

( 蛋白质的纯化与回收 )

Streamlining & Innovating Processes

2018年1月9日 - 10日

 

Cambridge Healthtech Institute's Protein Purification and Recovery conference examines the strategies that efficiently lead to pure protein for research or therapeutic use. As the most costly and time-consuming process in the manufacturing of protein-based therapies, purification poses continual challenges for streamlining steps and cutting costs. Challenges are multiplied when purifying complex molecules, such as membrane proteins, bispecifics and antibody-drug conjugates. This leading purification meeting explores how experts are optimizing processes to reach project goals in a timely way. Along with innovating 'traditional' technologies such as affinity tags, Protein A, and chromatography, leaders will also address alternatives and breakthroughs, such as continuous processing.

Preliminary Agenda

PURIFYING ANTIBODIES

KEYNOTE PRESENTATION:
Rapid High-Resolution Separation and Analysis of Monoclonal Antibody Samples Using Laterally-Fed Membrane Chromatography

Raja Ghosh, Ph.D., Professor and Canada Research Chair, Bioseparations Engineering, Chemical Engineering, McMaster University


Breakthrough Purification Strategies


FEATURED PRESENTATION:
Ten-Minute Protein Purification and Surface Tethering for Continuous-Flow Biocatalysis
Gregory Weiss, Ph.D., Professor, Chemistry, Molecular Biology and Biochemistry, University of California, Irvine (UCI)

Characterization of the Co-Elution of Host Cell Proteins with Monoclonal Antibodies during Protein A Purification

Qingchun Zhang, Ph.D., Senior Scientist, Amgen, Inc.

Optimization of an IgG-Binding, Protein A-Based Purification Matrix

Sophia Hober, Ph.D., Professor, Molecular Biotechnology, KTH - Royal Institute of Technology

Bigger, Brighter, Faster: Accelerating Protein Production by Enhancing Soluble Yield, Monitoring Expression and Compressing Chromatography Strategies

Christopher H. Gray, Ph.D., Team Leader, Structural Biology, Drug Discovery Program, CRUK Beatson Institute


Affinity Tags

An Introduction to HisMAB: An Antibody-Based Affinity Purification System for His Tagged Proteins

Jiansheng Wu, Ph.D., Principle Scientific Manager, Protein Chemistry, Genentech, Inc.

Engineering the Beta Roll Domain for Bioseparations Applications

Scott Banta, Ph.D., Professor, Chemical Engineering, Columbia University


Purifying Membrane Proteins

A Method for Detergent-Free Isolation of Membrane Proteins in their Local Lipid Environment

Timothy R. Dafforn, Ph.D., Professor, Biotechnology, University of Birmingham

Small Affinity Tags for Efficient Purification and Recovery of Integral Membrane Receptors

Alexei Yeliseev, Ph.D., Staff Scientist, LMBB, National Institutes of Health, NIH/NIAAA


* 活动内容有可能不事先告知作更动及调整。