Cambridge Healthtech Institute's Tenth Annual
Protein Purification and Recovery
( 蛋白质的纯化与回收 )
Streamlining & Innovating Processes
2018年1月9日 - 10日
Cambridge Healthtech Institute's Protein Purification and Recovery conference examines the strategies that efficiently lead to pure protein for research or therapeutic use. As the most costly and time-consuming process in the manufacturing of protein-based therapies, purification poses continual challenges for streamlining steps and cutting costs. Challenges are multiplied when purifying complex molecules, such as membrane proteins, bispecifics and antibody-drug conjugates. This leading purification meeting explores how experts are optimizing processes to reach project goals in a timely way. Along with innovating 'traditional' technologies such as affinity tags, Protein A, and chromatography, leaders will also address alternatives and breakthroughs, such as continuous processing.
Breakthrough Purification Strategies
Characterization of the Co-Elution of Host Cell Proteins with Monoclonal Antibodies during Protein A Purification
Qingchun Zhang, Ph.D., Senior Scientist, Amgen, Inc.
Optimization of an IgG-Binding, Protein A-Based Purification Matrix
Sophia Hober, Ph.D., Professor, Molecular Biotechnology, KTH - Royal Institute of Technology
Bigger, Brighter, Faster: Accelerating Protein Production by Enhancing Soluble Yield, Monitoring Expression and Compressing Chromatography Strategies
Christopher H. Gray, Ph.D., Team Leader, Structural Biology, Drug Discovery Program, CRUK Beatson Institute
An Introduction to HisMAB: An Antibody-Based Affinity Purification System for His Tagged Proteins
Jiansheng Wu, Ph.D., Principle Scientific Manager, Protein Chemistry, Genentech, Inc.
Engineering the Beta Roll Domain for Bioseparations Applications
Scott Banta, Ph.D., Professor, Chemical Engineering, Columbia University
Purifying Membrane Proteins
A Method for Detergent-Free Isolation of Membrane Proteins in their Local Lipid Environment
Timothy R. Dafforn, Ph.D., Professor, Biotechnology, University of Birmingham
Small Affinity Tags for Efficient Purification and Recovery of Integral Membrane Receptors
Alexei Yeliseev, Ph.D., Staff Scientist, LMBB, National Institutes of Health, NIH/NIAAA