Cambridge Healthtech Institute第三届

Oligonucleotide Discovery and Delivery

( 低聚核苷酸疗法的创药与运输 )


2018年3月26-28日 | Boston Marriott Cambridge | 马萨诸塞州剑桥



Who should attend: Executives, Directors, Managers, and Scientists from Pharma, Biotechs, Academia, Government and Healthcare Organizations working in fields such as Oligonucleotide Therapeutics, Immunotherapy, Gene Therapy, Gene Editing and Rare Diseases.

Topics will include, but are not limited to:

Therapeutic Oligonucleotides - Coverage Includes:

  • Antisense single-stranded DNA/RNA oligonucleotides (ASOs)
  • siRNA
  • mRNA
  • ncRNA
  • Aptamers

Part 1: Therapeutic Oligonucleotide Discovery and Development

  • Oligonucleotides for:
    • RNA modulation
    • Antivirals
    • Splicing modulation and exon skipping
    • DNAi
    • Gene editing
      • CRISPR/Cas9
  • Oligonucleotide Synthesis and Chemistry
  • Aptamer Therapeutics
  • Preclinical and Clinical Studies
  • Combination Strategies

Part 2: Delivery

  • Chemical Modifications and Conjugation
    • Improving stability, bioavailability, specificity and potency
  • Improved Oligonucleotide Delivery Methods
    • Nanomaterial-based delivery
    • Non-viral delivery systems
    • Small molecule based delivery
    • Delivery methods for non-hepatic targets
      • Blood-brain barrier
    • Delivery of large nucleic acids

Part 3: Oligonucleotides for Cancer Immunotherapy

  • RNA-Based Vaccines
    • Chemical modifications
    • Immuno-stimulatory adjuvants and co-stimulatory molecules
      • Toll-like receptor agonists
      • Targeting the STING pathway
    • Delivery of RNA vaccines
    • Non-viral delivery strategies
  • Dendritic Cell Vaccines
  • Preclinical and Clinical Combination Studies with Checkpoint Inhibitors
  • Novel Agents Inducing Immune Response
  • Novel Targets for Immunotherapy Development

The deadline for submission is September 15, 2017.

All proposals are subject to review by the Scientific Advisory Committee to ensure the highest quality of the conference program. Please note that due to limited speaking slots, preference is given to pharmaceutical and biotech companies, regulators and those from academia. Additionally, vendors/consultants who provide products and services to these biopharmaceutical companies are offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

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