- 合成及系统工程 -
The complexity of biotherapeutics and the increasing demands of “faster, better, less expensive” resonate with recombinant protein expression and production researchers. To meet these demands, protein scientists are exploring new engineering tools. However, many variables still must be considered during the engineering process, including verification and sequence analysis of the gene or protein of interest, codon optimisation, vector construction and clone/host selection. Ultimately, as with any new system, these tools must be weighed against traditional expression and production strategies to achieve the desired quantity and quality.

The Systems Engineering and Synthetic Biology conference applies effective engineering strategies for protein expression and production research leading to functional protein products. Learn from seasoned, savvy researchers as they share their real-world experiences, applications and results.


Preliminary Agenda


Plenary Keynote Session

Moderator's Opening Remarks

Janine Schuurman, PhD, Corporate Vice President, Research & Innovation, Genmab BV

Bicycles and Bicycle Drug Conjugates

Sir Gregory Winter, PhD, FRS, Master, Trinity College; Co-Founder and Director, Bicycle Therapeutics

Using Protein Engineering to Make Therapeutics in Situ

Andreas G. Plückthun, PhD, Professor and Director, Department of Biochemistry, University of Zürich


KEYNOTE PRESENTATION: From Systems Biology to Systems Biologics
Sachdev Sidhu, PhD, Professor, Molecular Genetics, The Donnelly Centre, University of Toronto

GENOME ENGINEERING

Engineering the Trichoplusia ni Insect Cell Line Tni-FNL to Improve Recombinant Protein Production
Dominic Esposito, PhD, Director, Protein Expression Laboratory, Frederick National Laboratory for Cancer Research

CRISPR-Cas Implementation and Novel Expression Tools for Non-Conventional Yeasts
Thomas Vogl, PhD, Researcher, Department of Computer Science and Applied Mathematics & Department of Molecular Cell Biology, Weizmann Institute of Science

Expanding the Synthetic Biology Toolbox for CHO Cell Factories
Helene Faustrup Kildegaard, PhD, Senior Researcher & Co-Principal Investigator, The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark

SYSTEMS ENGINEERING

Design of Intracellular Inhibitors – A Platform for Target Validation and Drug Development
Andreas Ernst, PhD, Group Leader, Institute of Clinical Pharmacology, Goethe University Frankfurt

Top-Down and Bottom-Up Strategies for Production of Human Multi-Protein Complexes
Arnaud Poterszman, PhD, Research Director, Integrated Structural Biology, IGBMC (CNRS/INSERM/UdS)

CELL-FREE SYSTEMS

Expanding One-Pot Cell-Free Protein Synthesis and Immobilization for On-Demand Manufacturing of Biomaterials
Fernando López-Gallego, PhD, ARAID Tenured Scientist, Institute of Synthetic Chemistry, University of Zaragoza

Cloning-Free Template DNA Preparation for a Wheat Germ Cell-Free System with Short 3'-UTR
Yasuomi Tada, PhD, Professor, Center for Gene Research, Nagoya University

Cell-Free Protein Synthesis from Resting versus Ultra-Fast Growing Cells: Findings from Systems Biology
Martin Siemann-Herzberg, PhD, Institute of Biochemical Engineering, University of Stuttgart


* 活动内容有可能不事先告知作更动及调整。

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