11月12日 (一)、11月13日 (二)
第1天: 13:30 - 19:30 | 第2天: 08:30 - 18:30
TS6A: Basic Technologies in a Protein Production Lab
This seminar is designed to introduce basic technologies, strategies and considerations in recombinant protein production in E. coli, insect and mammalian cells for multiple research and development applications. The seminar supplies a basic toolbox for management of multiple and diverse projects.
Tsafi Danieli, PhD, Director, BioGiv Excubator & Head, Protein Expression Facility, Wolfson Centre for Applied Structural Biology, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem; Mario Lebendiker, PhD, Head, Protein Purification Facility, Wolfson Centre for Applied Structural Biology, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem
Richard Altman, MS, Scientist, Protein Technologies, Amgen; Nicola Burgess-Brown, PhD, Principal Investigator, Biotechnology, Structural Genomics Consortium (SGC), University of Oxford; Henry C. Chiou, PhD, Associate Director, Cell Biology, Life Science Solutions, Thermo Fisher Scientific; Dominic Esposito, PhD, Director, Protein Expression Laboratory, Frederick National Laboratory for Cancer Research; Bjørn Voldborg, MSc, Director, CHO Cell Line Development, The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark
TS7A: Introduction to Bispecifics: History, Engineering, and Application
Intro to Bispecifics will be organized as an informative and practical guide to get up to speed on critical aspects of bispecific antibody therapeutics. Topics will include historical successes, failures, and lessons learned. Specific practical instruction will span mechanisms of action, engineering, developability, regulatory considerations, and translational guidelines. Perspectives on ideal implementation of bispecifics as targeted and immunomodulatory approaches will be discussed.
G. Jonah Rainey, PhD, CEO, Oriole Biotech, Inc.
TS8A: Introduction to Protein Engineering
CHI’s Introduction to Protein Engineering training seminar offers a comprehensive tutorial in the concepts, strategies and tools of protein engineering – and explains the role of this discipline in the progression of biotherapeutic research and development. The class is directed at scientists new to the industry or working in support roles, academic scientists and career protein scientists wanting a detailed update on the current state of the field.
David Bramhill, PhD, Founder, Bramhill Biological Consulting, LLC and Research Corporation Technologies
11月14日 (三)、11月15日 (四)
第1天: 08:30 - 19:45 | 第2天: 08:30 - 12:45
TS6B: Rational Approaches to Biologics Formulation & Delivery
This course will give participants an understanding of the basic principles of biologics formulation development and achieving long term product stability. Participants will gain an understanding of biochemical and biophysical properties of proteins and peptides, and how excipients and other strategies can be used to mitigate degradation. Focus will be on maximizing efficiency while maintaining regulatory compliance. Following which, we will discuss more complex formulation development topics and strategies for compatibility studies.
Christina Vessely, PhD, Senior Consultant, CMC, Analytical and Formulation Development, Biologics Consulting
TS7B: Next-Generation Sequencing for Antibody Discovery and Engineering
Part 1 of the training introduces antibody repertoires, exploring genetic background, generation of diversity, sequencing technologies and the computational tools available for analysis of antibody repertoire NGS data. Part 2 will focus on preprocessing and analysis of data, elucidating each step using the programming language R using examples from existing bioinformatics pipelines. Repertoire analysis content will provide statistical quantification and visualization of high-dimensional data. The course will be fully interactive with case studies.
Sai Reddy, PhD, Assistant Professor, Biosystems Science and Engineering, ETH Zurich, Switzerland; Simon Friedensohn, MSc, Research Assistant, Biosystems Science and Engineering, ETH Zurich, Switzerland
11月15日 (四)、11月16日 (五)
第1天: 14:00 - 17:00 | 第2天: 08:30 - 15:35
TS6C: Potency and Comparability for Cell and Gene Products
Extending potency assay concepts to cell, gene and tissue products is more challenging and often the most difficult aspect of characterising these products. Whenever changes are made, it is necessary to confirm they do not adversely impact the quality and therefore safety and efficacy of the product; this requires data beyond meeting current specifications. This training seminar will discuss the implementation and use of tools to enable characterisation, comparability and process development.
Christopher A. Bravery, PhD, Consulting Regulatory Scientist & Director, Advbiols