Cambridge Healthtech Institute’s 13th Annual

GPCR-Based Drug Discovery
( GPCR基础的新药发现 )


G protein-coupled receptors (GPCRs), which relay chemical signals such as hormones from outside to the inside of cells, are the targets of approximately a third of the medicines on the market today. However, many of the GPCR-acting medicines were discovered decades or more ago, without today’s more detailed knowledge about and tools for working with GPCRs. The receptors span the membrane seven times, thus are challenging to solubilize and study in vitro. Recent biophysical advances though have bypassed some of the membrane-embedded challenges and enabled GPCR structural insights and spurred new screening applications. The receptors’ signaling complexities due to their ability to couple to a variety of G proteins (biased signaling) are also now more understood and capitalized upon to design more selective drugs. CHI’s well-established GPCR-Based Drug Discovery conference will continue to convene prominent scientists in both academics and industry to share and discuss the latest advances in applied GPCR research ranging from new screening assays and biophysical techniques, to structure-based drug development to medicinal chemistry optimization case studies to examples of GPCR-targeted compounds in development.


Who should attend: Discovery Biologists, Structural Biologists, Membrane Protein Scientists, CNS Translational Researchers, Pharmacologists, Discovery Chemists, Medicinal Chemists, Biophysical Chemists, Computational Chemists, and X-ray Crystallographers from academics, biotech and pharma companies


Coverage will include, but is not limited to:                                        

  • Biased signaling and allosteric modulation, especially in context of CNS and opioid research
  • Biophysical techniques: NMR, fragment-based screening, SPR and biosensor-based assays, nanodiscs
  • CryoEM
  • GPCRs in CNS diseases, metabolic diseases, cancer and autoimmunity
  • Structural insights for SBDD and computational chemistry
  • GPCR trafficking and impact on pharmacology

* 活动内容有可能不事先告知作更动及调整。

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