( 革兰氏阴性病原菌的标靶化 )

New discovery platforms, novel screens and approaches are vital for the discovery of new antibacterials and for ceasing the dangerous trends of multidrug microbial resistance. Gram-negative bacteria are one of the main challenges for the healthcare system and public health in general. Gram-negative bacteria have specific scientific problems such as low permeability of the outer membrane that must be overcome, complicated and multiple resistance mechanisms, etc. Cambridge Healthtech Institute's 5thAnnual Antibacterial Discovery and Development and the 2nd Annual Targeting Gram-Negative Pathogens conference are designed as knowledge and experience exchanges for the major stakeholders working in this important area.

Part One:

New discovery platforms, novel screens and approaches are vital for the discovery of new antibacterials and for ceasing the dangerous trends of multidrug microbial resistance. Cambridge Healthtech Institute's 5th Annual Antibacterial Discovery and Development track will focus on the general, strategic issues and solutions that would allow new antibacterial development to move forward. The conference will be held as part of the 5th Annual Re-Entering Antibacterial Discovery and Development Summit, and it will be followed by Targeting Gram-Negative Pathogens.

Coverage will include, but is not limited to:

  • Clinical impact of multidrug-resistant infections
  • Addressing multi-pathogen infections
  • DNA-based platforms
  • Genomic data mining, using bioinformatics to find new compounds
  • Host vs. microbe approaches
  • Targeted strategies to uncover narrow-spectrum drugs
  • Combination antibacterial therapy and adjuvants
  • PK-PD approaches to support antibacterial drug discovery and development
  • β-lactam antibiotics and β-Lactamase inhibitors
  • In vivo models of animal infection
  • Regulatory challenges and accelerated pathways
  • Collaboration across industry, academia, and government
  • Market access and pricing
  • Artificial intelligence and machine learning  - what gaps do we have to fill before we can use it?
  • Microbiome strategies

Part Two:

Multidrug-resistant Gram-negative bacteria are one of the main challenges for the healthcare system and public health in general. Gram-negative bacteria have specific scientific problems such as low permeability of the outer membrane that must be overcome, complicated and multiple resistance mechanisms, etc. Cambridge Healthtech Institute's 2nd Annual Targeting Gram-Negative Pathogens conference will be taking place as a part of the Fourth Annual Re-Entering Antibacterial Discovery and Development Summit. It will be preceded by the more general Antibacterial Discovery and Development.

Coverage will include, but is not limited to:

  • Addressing permeability of Gram-negatives
  • Antibacterial biologics for Gram-negative pathogens
  • Medchem approaches for Gram-negative pathogens
  • Addressing mechanisms of resistance
  • Alternative/adjunct therapies for Gram-negatives
  • Update on GNB trials
  • Examining the role of rapid diagnostics

* 活动内容有可能不事先告知作更动及调整。

 

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