- 微生物群的标靶化 -
Basic and applied biomedical research from the Human Microbiome Project and other independent studies prove that a disruption of a stable microbiome ecosystem results in dysbioses. This imbalance leads to chronic disease and health conditions. There is great promise in correlating the microbiome compositions with these diseases and using the microbiome as a tool for therapeutic development. Cambridge Healthtech Institute’s 4th Annual Targeting the Microbiome tracks both the scientific and clinical progress being made to discover and develop microbiome-derived biomarkers, drug targets, and bioactive molecules as potential treatments for chronic disease and health conditions. Through interactive sessions and panel discussions, leading researchers and thought leaders will explore how the microbiome can become a potential point of intervention to impact progression to disease.
Day 1 | Day 2
Thursday, September 27
11:50 am Conference Registration Open
12:20 pm Plenary Keynote Program
2:00 Refreshment Break in the Exhibit Hall with Poster Viewing
Targeting the Microbiome in Obesity and Metabolic Disorders
2:45 Welcome Remarks
Cindy Crowninshield, RDN, LDN, HHC, Senior Conference Director, Cambridge Healthtech Institute
2:50 Chairperson’s Opening Remarks
2:55 Targeting the Human Host-Microbiome Interface in Metabolic Diseases
James Brown, PhD, Director, Computational Biology & Senior Fellow, GSK
3:25 Gut Microbiome Mediates Sex Differences in the Obesity and Metabolic Syndrome in Mice
Kanakaraju “Raj” Kaliannan, MD, Instructor, Medicine, Harvard Medical School; Senior Research Fellow, Laboratory for Lipid Medicine and Technology (LLMT), Massachusetts General Hospital
Gut microbiome mediates sex differences in the obesity and metabolic syndrome. Estrogen or estrogen-like compounds-induced elevated intestinal alkaline phosphatase levels and subsequent gut microbiome changes lower bacterial lipopolysaccharide production and gut permeability, resulting in reduced metabolic endotoxemia and systemic low-grade chronic inflammation with subsequent reduction in the susceptibility to develop western-diet-induced metabolic syndrome in estrogen treated males and post-menopausal women.
3:55 Small Molecules at the Intersection of Health and Microbiota
Karen DeBalsi, PhD, Senior Study, Director, Metabolon
Metabolites serve as a language that mediates cross-species relationships and Metabolon’s unbiased global metabolomics approach provides a great tool to decipher the complex biological story. This talk will cover how one can best leverage this technology to address their microbiome research questions as supported by case studies.
4:25 Refreshment Break in the Exhibit Hall with Poster Viewing
Targeting the Microbiome in Oral Health & Nutrition
5:00 The Oral Microbiome as a Gateway to Systemic Health
Bonnie Feldman, DDS, MBA, Digital Health Analyst and Chief Growth Officer, DrBonnie360
The oral cavity is home to an immensely diverse microbiome: an estimated 20 billion microbes (more than 700 species) live in our mouths, with distinct populations predominating in different oral habitats. The status of our oral microbiome and health may provide an early indicator of systemic diseases such as diabetes, heart disease, stroke, rheumatoid arthritis and other autoimmune diseases. As advances in big data analytics, next-generation sequencing, and systems immunology advance our knowledge about the human microbiome, our understanding of and approach toward oral health, systemic immunity, and systemic health will also evolve. Learn about the latest research connecting the oral microbiome and gut with chronic and autoimmune diseases and systemic health.
5:30 Nutrition and the Gut Microbiome: Where Are We Now? Where Are We Going?
Leigh A. Frame, PhD, MHS, Program Director, Integrative Medicine, The George Washington University School of Medicine and Health Sciences
When the gut microbiome (gBiome) is in an unhealthy state, an individual is in dysbiosis, which may be related to their diet and its nutritional value. The role of nutrition and the gBiome in health and disease has rapidly grown with the understanding of each, their interactions, and the links to gastrointestinal disease, obesity, and chronic disease. In the last decade, the availability of affordable next-generation sequencing and gnotobiotics (germ-free animal models) has facilitated a major advancement in our understanding of the gBiome and the interaction with nutrition.
6:00 Talk Title to be Announced
John Hale, PhD, Research and Development Manager, BLIS Technologies
6:30 Dinner Short Course Registration
9:30 Close of Day
Day 1 | Day 2
Friday, September 28
7:00 am Registration Open
7:30 Interactive Breakfast Breakout Discussion Groups
Grab a cup of coffee and join a breakout discussion group. These are informal, moderated discussions with brainstorming and interactive problem solving, allowing participants from diverse backgrounds to exchange ideas and experiences and develop future collaborations around a focused topic. Details on the topics and moderators are available on the conference website.
TARGETING THE MICROBIOME IN AUTOIMMUNITY AND INFLAMMATORY BOWEL DISEASE
8:30 Chairperson’s Remarks
Thomas Sundberg, PhD, Senior Research Scientist I, Center for Development of Therapeutics, Broad Institute of MIT and Harvard
8:35 KEYNOTE PRESENTATION: NOD2, Innate Immunity and the Microbiome
Catherine Grimes, PhD, Assistant Professor, Department of Chemistry and Biochemistry, University of Delaware
9:05 Reverse Translation for Therapeutic Development in the Human Microbiome
Ulrich Thienel, MD, PhD, CMO, Finch Therapeutics, Inc.
A major challenge in microbiome research is interpreting correlations observed in human cohort studies or murine models. However, with the increasing abundance of clinical interventional data from experience with fecal microbiota transplantation, there is an opportunity to develop therapeutic insights directly from clinical observations. Finch Therapeutics identifies microbial therapies by observing patterns of microbial engraftment that drive clinical responses. We plan to use the patterns to develop a new generation of rationally selected microbiota therapies for Inflammatory Bowel Disease.
9:35 Presentation to be Announced
10:05 Coffee Break in the Exhibit Hall with Poster Viewing and Poster Competition Winner Announced
Commercializing Translational Applications & Microbiome Products
10:45 Standards for Microbiome and Metagenomics: Supporting the Commercial Translation of Microbiome Science
Scott Jackson, PhD, Molecular Genetics and Microbial Genomics, National Institute of Standards and Technology
At NIST, we are improving microbiome science and supporting the National Microbiome Initiative by developing standards for microbiome measurements that will enable federal, academic, and industry labs to reliably reproduce and advance each other’s results. Microbiome standards will support research investigations and commercial translation of microbiome science by providing measurement assurance tools: standardized protocols, reference materials, validated measurements and critically evaluated reference data.
11:15 Considerations in Developing a Microbiome Therapeutic
Jeannie Rojas, PhD, MBA, Portfolio Leader, Research and Development, Janssen R&D
When developing a commercial microbiome product, the development pathway and regulatory submission strategy will be different depending on whether the product is a medical food, dietary supplement or prescription drug. Microbiome-based products are novel and available guidelines are open to interpretation. In this talk, I will walk through the process of bringing a microbiome-based therapeutic to the clinic, with emphasis on key considerations, hurdles and challenges that must be factored into the development process.
11:45 Sponsored Presentation (Opportunity Available)
12:15 pm Session Break
12:25 Luncheon Presentation (Sponsorship Opportunity Available) or Enjoy Lunch on Your Own
1:15 Refreshment Break in the Exhibit Hall with Poster Viewing
Microbiome Market, Development & Investment Opportunities
1:55 Chairperson’s Remarks
Keith F. Batchelder, MD, CEO and Founder, Genomic Healthcare Strategies
2:00 Human Microbiome Growth Opportunities and Predictions
Sudeep Basu, PhD, Practice Leader, TechVision-Innovation Services, Frost & Sullivan
This presentation focuses on recent development in the areas of microbiome-driven therapeutics. An overview of key research groups, disease focus areas and trends will be provided. The discussion will encompass a review of select technologies, markets and products as well.
2:30 PANEL DISCUSSION: From Microbiome to Market: Exploring Business Development Opportunities and Investment Models
Keith F. Batchelder, MD, CEO and Founder, Genomic Healthcare Strategies (Moderator)
David Donabedian, PhD, Venture Partner, Longwood Fund; CEO and Co-founder of Longwood portfolio Company Axial Biotherapeutics, Inc.
Jeannie Rojas, PhD, MBA, Portfolio Leader, Research and Development, Janssen R&D
Additional Panelists to be Announced
This panel discussion is appropriate for you if you are working in research, science or industry and have questions about translation opportunities or the kinds of business and financial models that investors find attractive. We will discuss the areas of the microbiome investors are looking at and why. We will explore the global scope of microbiome and successful collaboration, reimbursement, and business investment models between science, business, healthcare, and government in bringing live microbial products to market. We will also discuss balancing venture activities, external R&D, and long-term market opportunities. Join us for a lively and interactive discussion.
4:00 Close of Conference