Cambridge Healthtech Institute’s 6th Annual
Targeting the Ubiquitin-Proteasome System
( 泛素蛋白酶体系统的标靶化 )
The ubiquitin-proteasome system (UPS) is a well-controlled, selective mechanism for intracellular protein degradation and turnover. New understanding of the role and molecular mechanisms involved in the dysregulation of the UPS has led to its emergence as a key regulator of protein function and stability. Although implicated to play a role in cancer, CNS, infectious diseases and more, the multi-step processes involved, and the diversity of substrates makes it difficult to target the UPS. However, in recent years, the development of high-quality chemical probes and assay technologies has turned it into one of the most exciting targets for discovering novel drugs. In the UPS, the ligases and deubiquitinases (DUBs) have recently attracted a lot of attention as possible targets for clinical intervention. Cambridge Healthtech Institute’s Targeting the Ubiquitin-Proteasome System conference will bring together a diverse group of chemists and biologists to discuss the promise and challenges in modulating the UPS. This conference will be preceded by a symposium that focuses on targeting autophagy pathways and will draw on some of the synergies between these two areas of research.
Who should attend: SCIENTISTS and EXECUTIVES from Pharma, Biotech, Academia, Government, Contract Research Labs and Technology Providers involved in target ID & validation, discovery biology, cancer biology, immunology, discovery chemistry, biochemistry, molecular & cell biology, phenotypic screening, assay development, chemical biology, and other areas related to early drug discovery & development.
Coverage will include, but is not limited to:
- Emerging approaches for targeting the ubiquitin cascade
- New probes and inhibitors targeting DUBs, E2 and E3 ligases
- Novel bivalent inhibitors for hijacking the UPS and targeted protein degradation
- Targeting ubiquitin-like molecules
- Exploring PROTACS, hydrophobic tagging, and strategies to disrupt protein-protein interactions
- New tools and assays to study and modulate the UPS biology
- Translating lessons learned from kinase drug discovery
- Tackling challenges with specificity and toxicity