Cambridge Healthtech Institute第5届

Adoptive T Cell Therapy 1: Discovery

( 过继T细胞免疫疗法1:创药 )

2018年8月28日~29日


本单元以过继T细胞免疫疗法的创药为主题,内容将聚焦于选定、改变、强化、向病患提供具有发展潜力的T细胞疗法药物之必要步骤。

Coverage will include, but is not limited to:

Principles of engineered receptor design

  • Chimeric antigen receptors (CAR)
  • T cell receptors (TCR)
  • Tumor infiltrating lymphocytes (TIL)

Other cellular subtypes

  • Natural killer cells (NK)
  • Cytotoxid T lymphocytes (CTLs)
  • Tregs

Advances in the selection of optimal T cells

New techniques in T cell engineering

  • Gating strategies
  • Antigen presentation
  • New approaches to activation and engagement

Biological switches

  • Kill switches
  • Activation switches

Toxicity

  • Understanding mechanisms
  • Evolution of synthetic cells and their long-term efficacy

Genome editing

  • CRISPR/Cas9
  • Zinc finger nucleases
  • TAL

Enabling technologies and platforms

* 活动内容有可能不事先告知作更动及调整。

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