Cambridge Healthtech Institute’s 4th Annual

Biophysical Approaches for Drug Discovery
( 新药发现的生物物理学方法 )

New Methods and Lead Generation Strategies for Medicinal Chemists

2019年4月12日

 

Recent advances in automation and sensitivity of biophysical approaches for measuring biomolecules interacting with one another has spurred progress in drug discovery. Technologies such as nuclear magnetic resonance (NMR), surface plasmon resonance (SPR), other biosensor-based assays, isothermal titration calorimetry (ITC), and thermal shift assays (TSAs) have enabled discovery of compounds targeting protein-protein interactions and complex membrane protein targets. These target classes are more difficult to ‘drug’ because they are either harder to solubilize or not as amenable as are traditional intracellular enzyme targets to in-vitro-based, biochemical functional assays for high throughput screening. Fragment-based drug design is also another lead generation approach that is very dependent on biophysical technologies. Cambridge Healthtech Institute's 4th Annual Biophysical Approaches for Drug Discovery symposium will bring together medicinal chemists, structural biologists, biophysical chemists and computational researchers to discuss the latest biophysical advances and see examples and discuss strategies for when to apply them for more efficient drug lead generation.

Coverage will include, but is not limited to:

  • Advances in biophysical technologies used for drug discovery (NMR, SPR, mass spectrometry, ITC, TSAs)
  • Biophysical innovations for screening fragment-based libraries
  • New tools for measuring protein conformational changes
  • Using biophysical techniques for better drug lead generation, especially against PPIs and membrane proteins
  • Case studies of lead generation via integrating various biophysical approaches
  • Applications of biophysical technologies for secondary screens

* 活动内容有可能不事先告知作更动及调整。