Cambridge Healthtech Institute’s Inaugural

Directed Evolution-Based Drug Discovery
( 基于指向性进化法的新药发现 )

DNA Encoded Libraries and Other Diversity Oriented Platforms


Directed evolution approaches for drug discovery use genetic strategies (DNA-encoded, RNA-encoded or phage-based) to create very large but specific libraries of molecules whose amplification is driven by the target of interest. The theory was established decades ago but recently applications in early stage drug discovery have become more widespread. A few drug candidates arising from directed evolution campaigns are now in clinical trials. A bottleneck however of these diversity-oriented strategies is figuring out which hits to focus on from the many hits that are produced by these approaches. Cambridge Healthtech Institute's Inaugural Directed Evolution-Based Drug Discovery conference will cover challenges, innovations, best practices and case studies in three of the major diversity-oriented platforms: DNA encoded libraries, mRNA-directed technologies and phage display.

Coverage will include, but is not limited to:

  • Innovations in each of three directed evolution, diversity-oriented platforms
  • Dealing with bottlenecks and other challenges of each platform (e.g. hit to lead optimization)
  • Case studies of drug candidates resulting from the three directed evolution platforms
  • Comparing diversity-oriented approaches to other lead generation strategies such as high throughput screening and fragment-based drug design

* 活动内容有可能不事先告知作更动及调整。