Cambridge Healthtech Institute’s 2nd Annual

Targeting the Ubiquitin-Proteasome System
( 泛素蛋白酶体系统的标靶化 )

Novel Tools and Compounds to Modulate DUBs, Ligases and Other Proteins

2019年4月10日~11日

 

The ubiquitin-proteasome system (UPS) is a complex, highly regulated network of proteins that is responsible for intracellular protein degradation and turnover. Advances in our understanding of the role and molecular mechanisms of the UPS components in disease and the development of high quality chemical tools and inhibitors have turned the previously “undruggable” UPS targets into an exciting opportunity for small molecule drug intervention. Over the past years, we have seen the development of a new generation of deubiquitinating enzymes (DUBs) and proteasome inhibitors poised for clinical development, as well as the discovery of novel inhibitors for disrupting the protein-protein interactions in ligases and hijacking the UPS for targeted protein degradation. Cambridge Healthtech Institute’s conference on Targeting the Ubiquitin-Proteasome System will bring together an expert group of chemists and biologists who are working to advance this rapidly growing field of ubiquitin drug discovery.

Coverage will include, but is not limited to:

 

  • Novel probes and inhibitors targeting DUBs, E2 and E3 ligases, and other proteins in the ubiquitin cascade
  • Hijacking the UPS for targeted protein degradation
  • Exploring PROTACS, hydrophobic tagging and other strategies to disrupt protein-protein interactions (PPI)
  • Case studies describing the identification, characterization and validation of small molecule ubiquitin inhibitors
  • New assay platforms for identifying selective ubiquitin inhibitors and probes
  • Targeting ubiquitin-like molecules
  • Translating lessons learned from kinase drug discovery
  • Tackling challenges with specificity and toxicity 

* 活动内容有可能不事先告知作更动及调整。