Cambridge Healthtech Institute’s 7th Annual

Biophysical and Structural Analysis
( 生物物理学和结构分析 )

Implementing Emerging Technologies for Improved Product Quality and Accelerated Development Timelines

2019年4月10~11日

 

Biophysical and structural analysis are now playing increasingly important roles in the discovery and development of next generation biotherapeutics. Developability assessment is now standard practice across the industry, and understandings gained at this step are now being applied in the optimization of candidates at early stages of the pipeline. Higher resolution tools are enabling better understandings of how to characterize and control aggregation and particulates and are increasingly allowing these methods to be used in a quantitative, rather than qualitative way. The PEGS “Biophysical and Structural Analysis” conference brings together an international audience of protein scientists and analytical specialists to explore the latest technologies and methods for problem solving in this dynamic field and identify ways of optimizing the studies performed in support of regulatory filings and manufacturing.

Preliminary Agenda

CHARACTERIZING HIGHER ORDER STRUCTURE

Characterization of Therapeutic Proteins by Circular Dichroism Spectroscopy: Application to Process Comparability and Establishment of Critical Quality Attributes

Gurusamy Balakrishnan, PhD, Scientist, Bristol-Myers Squibb

Ion Mobility Spectrometry Mass Spectrometry (IMS-MS) for HOS Characterization

Brandon Ruotolo, PhD, Professor, Chemistry, University of Michigan

KEYNOTE PRESENTATION: The (Non)sense of Some Approaches for HOS Analysis

Laurent Larivière, PhD, Head, Mass Spectrometry, Large Molecule Research, Roche Pharma Research and Early Development (pRED), Germany

IMPLEMENTING THE MULTI-ATTRIBUTE-METHOD (MAM)

QC-Friendly MAM Method Development and Qualification

Jihong Wang, PhD, Principal Scientist, MedImmune

Implementing the Multi-Attribute Method in an Analytical Development Group: Successes and Challenges

Kristin Boggio, PhD, Senior Scientist, Protein Mass Spectrometry, Pfizer

Development of MS-Based Multi-Attribute Methods for ADC Process Support

Lintao Wang, PhD, Associate Director, Analytical and Pharmaceutical Development, ImmunoGen, Inc.

Presentation to be Announced


Luncheon Presentation to be Announced


METHODS AND INSTRUMENTS

Leveraging Force Degraded Material to Increase the Throughput of Peptide Map Characterization

Romesh Rao, Research Associate, Seattle Genetics

PULSE-SPR and Its Applications in Developability Assessment

Li Zhou, PhD, Senior Scientist, Global Biologics, AbbVie

Advances in High-Throughput Screening for Development and Formulation of Biologics

John Champagne, PhD, Senior Applications Scientist, Northeast Regional Manager, Sales, Wyatt Technology


SPECTROMETRY METHODS

Cutting-Edge Chromatographic and Mass Spectrometry Characterization of mAbs, Fc-Fusion Proteins and ADCs

Alain Beck, PhD, Head, Physico-Chemistry, Pierre Fabre, France

The Application of Fourier Transform Ion Cyclotron Resonance MS and Spectral Deconvolution Algorithms within Biopharma Research

Iain D. G. Campuzano, Principal Scientist, Discovery Attribute Sciences, Amgen

AGGREGATION AND STABILITY

Ultrafast High-Resolution Protein Analysis Unconventional Devices

Raja Ghosh, PhD, Professor, Chemical Engineering, McMaster University, Canada

Effect of L-proline, L-arginine.HCl and NaCl on the Aggregation and Viscosity Behavior of High-Concentration Antibody Formulations

Chaitanya Sudrik, PhD, Postdoctoral Researcher, Molecular Engineering, Massachusetts Institute of Technology

Impact of Non-Ideal Analyte Behavior on the Separation of Protein Aggregates by Asymmetric Flow Field-Flow Fractionation

Björn Boll, PhD, Head, Particle Lab and Higher Order Structure Protein Analytics, Novartis Pharma AG, Switzerland


* 活动内容有可能不事先告知作更动及调整。

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