Cambridge Healthtech Institute’s 9th Annual

Optimizing Protein Expression
( 蛋白质表现和优化 )

Enhancing Expression Systems

2019年4月10~11日

 

Expression of heterologous proteins presents many challenges and understanding expression systems is key. The 9th annual Optimizing Protein Expression conference delves into protein expression by examining and enhancing expression systems, including CHO and other mammalian systems, E. coli, yeast and baculovirus. What is the best expression system for expressing your protein of choice? Ease and cost of scale-up must be considered to ensure successful bottom-line results. Experts will share case studies and disclose data while divulging details of expression systems’ underlying mechanisms. Comparing and contrasting systems will also be featured to increase understanding in the quest for greater productivity.

Preliminary Agenda

PROTEIN PRODUCTION STRATEGIES

KEYNOTE PRESENTATION:
New Strategies for Productivity in the Development of Innovative Therapeutic Molecules

Nicola Beaucamp, PhD, Head, Process Research, Roche Innovation Center Munich, Pharma Research and Early Development, Roche Diagnostics GmbH

Site-Specific Biotinylation of Secreted Proteins in Mammalian Cells In Vivo -- Made Viable!

Mark Trautwein, PhD, Senior Scientist, Pharmaceuticals R&D, Preclinical Research, Expression Technologies, Bayer AG

Generation of Superior Host Cell Lines for Biomanufacturing

Holger Laux, PhD, Fellow, Cell Line Development, Novartis Institutes for BioMedical Research, Novartis AG 

 

KuhnerShakerLuncheon Presentation to be Announced

 

 

OPTIMIZING CHO-BASED EXPRESSION

Achieving Predictable Recombinant Gene Expression in CHO Cells Using CRISPR-Mediated Genome Engineering

Nuša Pristovšek, PhD, Postdoctoral Researcher, The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark

Combining Biophysical Analytics with NGS-Based Genetic Characterization and Gene Editing Technologies to Improve mAb Producing CHO Cell Lines

Holger Thie, PhD, Senior Manager, Technology and Innovation, Biologics Development, Boehringer Ingelheim Pharma GmbH & Co. KG

Importance of Appropriately Glycosylated Species, and Modulation Efforts, to Achieve Desired Post-Translational Modification in CHO-Derived Monoclonal Antibodies

Gaurav Chauhan, MS, Associate Principal Scientist, BioProcess Development, Merck & Co., Inc.

Engineering CHO Cell Lines for the Production of Hard-to-Produce Proteins

Bjørn Voldborg, MSc, Director, CHO Cell Line Development, The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark

New Tools for Screening & Harvesting Solutions for CHO & HEK293 Cells , for both Transient and Stable Cell

Samuel Ellis, Vice President, Thomson Instrument Company


ESCHERICHIA COLI

Expression Optimization of Antibody Fab Fragments in Escherichia coli with Non-Native Amino Acid (NNAA) Incorporated

Harun Rashid, PhD, Senior Principal Scientist, Molecular Technology, Ambrx, Inc.

AbsoluteAntibodyPresentation to be Announced

COMPARE / CONTRAST EXPRESSION SYSTEMS

Microbial or Mammalian Cells for Expression of Therapeutic Antibody Fragments: Making the Choice with the End in Mind

Philippe Billiald, PharmD, PhD, Professor, Biochemistry, University Paris-Sud & Acticor Biotech

Presentation to be Announced


Overcoming Limitations of Conventional Tag Systems – Strep-Tactin®XT Applications

Dennis Karthaus, MSc, IBA Lifesciences


* 活动内容有可能不事先告知作更动及调整。

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