团体讨论

Interactive Breakout Discussions are informal, moderated discussions, allowing participants to exchange ideas and experiences and develop future collaborations around a focused topic. Each discussion will be led by a facilitator who keeps the discussion on track and the group engaged. To get the most out of this format, please come prepared to share examples from your work, be a part of a collective, problem-solving session, and participate in active idea sharing. 

2024年4月25日（四） 12:05 - 13:05

Breakout Discussions with Hosted Luncheon

NEXT GENERATION CELL-BASED IMMUNOTHERAPIES

TOPIC: Optimizing Cell Therapy: Antigen Selection, Sequence and Targeting Strategies
Moderator: Sebastian Kobold, MD, Professor, Clinical Pharmacology, Klinikum der Universitat Munchen

• How can we pick the best antigens for targeting?
• How many antigens and in which sequence do we need?
• What would the properties of ideal adaptors or modules for cell therapy look like?
• Will targeting be enough?

TOPIC: Engineering Strategies for Next-Generation CAR T Cells
Moderator: Michael Traxlmayr, PhD, Group leader, CD Laboratory for Next-Generation CAR T Cells, University of Natural Resources & Life Sciences

• Logic gated CAR T cells
• Small molecule-regulated switches to control CAR T cell function
• Improving efficacy, while maintaining safety

BISPECIFIC AND MULTI-SPECIFIC ANTIBODY THERAPEUTICS

TOPIC: Optimizing Engineering of Bi and Multi-specific Antibodies
Moderator: Hikaru Koga, MS, Research Scientist, Biologics R&D, Chugai Pharmaceutical Co. Ltd.

• Optimizing binding affinity
• Mitigating off-target effects
• Improving stability
• Engineering for optimal manufacturability and scalability
• Leveraging computational tools

TOPIC: Bi and Multi-Specific Antibody Discovery and Emerging Formats
Moderator: Ruud de Wildt, PhD, Vice President, Pipeline Delivery, T-Therapeutics

• Novel formats being explored for therapeutic applications
• Advantages and disadvantages of certain formats
• Current challenges and future directions