培训研讨会
2025年1月13日(星期一) 9:00 am - 6:00 pm
TS1A: Introduction to Machine Learning for Biologics Design
- Basics of machine learning and where does it fit into drug discovery
- Modern homology modeling and structure prediction
- Predicting antibody affinity and specificity modulation
- Generative design in biologics: library design and language models
- Machine learning applications of T-cell and B-cell Immunogenicity
- Methods and application of ML for chemical, folding, solution stabilities
INSTRUCTOR BIOGRAPHIES:
Christopher R. Corbeil, PhD, Research Officer, Human Health Therapeutics, National Research Council Canada
Francis Gaudreault, PhD, Associate Research Officer, Human Health Therapeutics, National Research Council Canada
TS2A: Implementing Artificial Intelligence and Computational Tools in Biopharmaceutical R&D
Attendees do not need a deep computational background but will be introduced to cloud computing and containerized workflows in a hands-on fashion and should be familiar with basic concepts of programming and command line operations.
Topics to be covered:
- Identifying opportunities for AI/ML tools in existing and new programs
- Evaluating internal staff and experimental capabilities
- The role of ML scientists; do these need to be internal?
- Scoping, developing and sourcing training data
- Bespoke versus off-the-shelf models
- Cloud computing and containerized workflows
- Identifying drug targets in silico
- Protein structure prediction
- Antibody design and developability
- Small molecule design
- Designing de novo proteins with deep learning
INSTRUCTOR BIOGRAPHIES:
Ryan Peckner, PhD, Director, Machine Learning, Seismic Therapeutic
* 活动内容有可能不事先告知作更动及调整。