Main Conference - Day 2 (May 13)
6:30am - 7:30am60 minsFree
Fun Run
TIDES Fun Run & Walk
7:15am - 7:45am30 mins
Registration
Registration
Breakfast Spotlight Presentations
Concurrent Tracks
8:25am - 8:30am5 mins
Oligonucleotide Discovery, Preclinical and Clinical
Chairman’s Remarks: Advances in Oligonucleotide Medicinal Chemistry & Preclinical
8:25am - 8:30am5 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Chairman’s Remarks: Emerging Approaches to Enzymatic Synthesis for DNA and RNA: Challenges and Prospects
8:25am - 8:30am5 mins
Peptide Discovery to CMC
Chairman’s Remarks: Targeted Peptide Radiopharmaceuticals
8:25am - 8:30am5 mins
mRNA Technology and Applications
Chairman’s Remarks: mRNA Manufacturing and CMC Strategies
8:25am - 8:30am5 mins
Delivery of Macromolecules
Chairman’s Remarks: Genome Editing Delivery
8:30am - 9:00am30 mins
Oligonucleotide Discovery, Preclinical and Clinical
The Impact of Phosphoryl Guanidine (PN) Backbone Linkages on AIMer-mediated RNA Editing Across Cell and Tissue Types
8:30am - 9:00am30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Emerging Approaches to Enzymatic Synthesis of Nucleic Acids
8:30am - 9:00am30 mins
Peptide Discovery to CMC
Progress in the Development of Targeted Peptide Radiopharmaceuticals: Challenges, Successes and Case Studies
8:30am - 9:00am30 mins
mRNA Technology and Applications
Biofoundry-in-a-Box™: By-Design mRNA Manufacturing in a Box
8:30am - 9:00am30 mins
Delivery of Macromolecules
Delivery Strategies for Genome Editing
9:00am - 9:30am30 mins
Oligonucleotide Discovery, Preclinical and Clinical
From Seed to Solution: Ionis’ Answer to siRNA Off-Target Effects
9:00am - 9:30am30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Meeting the Manufacturing Needs of Nucleic Acids Used in Modern Medicines: Novel and Efficient Enzymatic Processes for mRNA and Oligonucleotide Synthesis
9:00am - 9:30am30 mins
Peptide Discovery to CMC
New Strategies for Prolonging Tumor Retention of Radioconjugates - An Example from FAP-directed RLT
9:00am - 9:30am30 mins
mRNA Technology and Applications
Addressing Manufacturing Challenges: Intensified, Continuous and Digitalised Production of High-quality mRNA Medicines at Low Cost
9:00am - 9:30am30 mins
Delivery of Macromolecules
Innovations in Delivery Technologies to Advance Base Editing to the Clinic
9:30am - 10:00am30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Next-generation Sequence-specific DNA-targeted Inhibitors
9:30am - 10:00am30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Oligonucleotide CMC for Sustainable and Scalable Enzymatic siRNA Manufacturing
9:30am - 10:00am30 mins
Peptide Discovery to CMC
68Ga/225Ac-FL-031, A New Generation of Theranostic Pair for the Treatment of SSTR2-positive Cancers
9:30am - 10:00am30 mins
mRNA Technology and Applications
mRNA Manufacturing: Mastering Impurity Detection and Removal for Enhanced Performance
9:30am - 10:00am30 mins
Delivery of Macromolecules
Optimization and Characterization of mRNA/LNPs for Targeted Delivery in vivo
Networking Refreshment Break in Poster and Exhibit Hall
10:00am - 10:45am45 mins
Networking Refreshment Break in Poster and Exhibit Hall
Networking Refreshment Break in Poster and Exhibit Hall
10:20am - 10:30am10 mins
TIDES Talks in Poster and Exhibit Hall
A Mild Cleavage and Deprotection Method for RNA Oligonucleotides Synthesized on Universal Supports
- Takaki Habuchi, PhD - Research Associate, Nippon Shokubai
10:30am - 10:40am10 mins
TIDES Talks in Poster and Exhibit Hall
TIDES Talk
10:45am - 11:15am30 mins
Oligonucleotide Discovery, Preclinical and Clinical
The Impact of Nucleoside Analogs on the Activity of Oligonucleotides that Direct ADARs for Therapeutic RNA Editing
10:45am - 11:15am30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Solving the Scale Problem: Template-independent Enzymatic Synthesis of siRNA Oligonucleotides
10:45am - 11:15am30 mins
Peptide Discovery to CMC
Bicycle® Radionuclide Conjugates for Radioisotope Delivery to Solid Tumors
10:45am - 11:15am30 mins
mRNA Technology and Applications
Evolving Lipid Nanoparticles to Optimize Clinical Application of messenger RNA Therapeutics
10:45am - 11:15am30 mins
Delivery of Macromolecules
Innovating Nucleic Acid Delivery: RAPTOR, Artificial Intelligence, and the Future of CAR-M
11:15am - 11:45am30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Recent Updates on Guanidine Bridged Nucleic Acid (GuNA) and 5′-cyclopropylene DNA (5′-CP), Demonstrating Their Potential to Improve Tolerability and Potency of Therapeutic Oligonucleotides
11:15am - 11:45am30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
DNA and RNA Libraries Produced though Massively Parallel, Light-directed Microarray Synthesis
11:15am - 11:45am30 mins
Peptide Discovery to CMC
From Discovery to First-in-Human Application of a Targeted Radiotherapeutic against Fibroblast Activation Protein Alpha (FAPa)
11:15am - 11:45am30 mins
mRNA Technology and Applications
Adapting LNP Platform Manufacturing Methods to Enable Clinical Applications of Next Generation mRNA-LNP Therapeutics
11:15am - 11:45am30 mins
Delivery of Macromolecules
Inhaled and In Vivo SORT LNP Delivery of RNA and Gene Editing Therapies
11:45am - 12:15pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Design, Synthesis, and Characterization of Novel 2ʹ-O-Substituted siRNAs for Targeting Hepatitis B Virus
11:45am - 12:15pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Chemical Synthesis of Long Oligos
11:45am - 12:15pm30 mins
Peptide Discovery to CMC
Translational Development of a Somatostatin Analog for Intraoperative Imaging in Neuroendocrine Tumors
11:45am - 12:15pm30 mins
mRNA Technology and Applications
A Single-Dose Thermostable LNP Platform for Prophylactic mRNA Vaccines
11:45am - 12:15pm30 mins
Delivery of Macromolecules
Delivering Gene Editing Therapeutics, mRNA Cargoes and siRNA
12:15pm - 12:20pm5 mins
Oligonucleotide Discovery, Preclinical and Clinical
Transition to Spotlight Presentation Rooms
12:15pm - 12:20pm5 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Transition to Spotlight Presentation Rooms
12:15pm - 12:20pm5 mins
Peptide Discovery to CMC
Transition to Spotlight Presentation Rooms
12:15pm - 12:20pm5 mins
mRNA Technology and Applications
Transition to Spotlight Presentation Rooms
12:15pm - 12:20pm5 mins
Delivery of Macromolecules
Transition to Spotlight Presentation Rooms
Spotlight Presentations
12:20pm - 12:50pm30 mins
Spotlight Presentation 2
Advances in LC separations, MS detection, and statistical analyses for characterizing oligonucleotide therapeutics for advancing new and generic drug development.
- Jace Jones, PhD - Associate Professor and Vice Chair for Education Associate Director of the Mass Spectrometry Center Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy
12:20pm - 12:50pm30 mins
Spotlight Presentation 4
OCELOT®: The Open, Unified Software Platform for Modern Oligo Manufacturing
- Stefan Hyde - Automation Manager, Asahi Kasei Bioprocess America
12:50pm - 1:55pm65 mins
Networking Luncheon in Poster and Exhibit Hall
Networking Luncheon in Poster and Exhibit Hall
1:20pm - 1:30pm10 mins
TIDES Talks in Poster and Exhibit Hall
Nanostar Sieving: A Scalable, Fully Liquid Phase Oligonucleotide Synthesis Platform
- Andrew Livingston - Chief Executive Officer, Exactmer
1:30pm - 1:40pm10 mins
TIDES Talks in Poster and Exhibit Hall
FISTag: A New Tool in the LPPS Arena
- Roberto Profeta - R&D Manager, F.I.S. Fabbrica Italiana Sintetici
1:40pm - 1:50pm10 mins
TIDES Talks in Poster and Exhibit Hall
mRNA/LNP Projects - from Gene to IND and Beyond
Concurrent Tracks
1:55pm - 2:00pm5 mins
Oligonucleotide Discovery, Preclinical and Clinical
Co-Chairs' Remarks: From Novel RNA Technologies to Therapeutics
1:55pm - 2:00pm5 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Chairman’s Remarks: Oligonucleotide CMC Strategies and Case Studies
1:55pm - 2:00pm5 mins
Peptide Discovery to CMC
Chairman’s Remarks: CIPPS Session: Unleashing the Power of Peptides for Therapeutics and Agriculture
1:55pm - 2:00pm5 mins
mRNA Technology and Applications
Chairman’s Remarks: mRNA Preclinical and Clinical Data
1:55pm - 2:00pm5 mins
Delivery of Macromolecules
Chairman’s Remarks: Novel Drug Delivery
2:00pm - 2:30pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Novel Design of Self-amplifying RNA and Formulation Challenges of Large RNA Payloads
2:00pm - 2:30pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Merging New Technologies to Advance the Synthesis of Oligonucleotides
2:00pm - 2:30pm30 mins
Peptide Discovery to CMC
Peptide-lipid Interplay: Unravelling How Bioactive Peptides Permeate Cell Membranes
2:00pm - 2:30pm30 mins
mRNA Technology and Applications
In Vivo Engineering of Cells using Targeted Lipid Nanoparticles
2:00pm - 2:30pm30 mins
Delivery of Macromolecules
Rational Design of Lipid Nanoparticles for Extrahepatic Nucleic Acid Delivery
2:30pm - 3:00pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Programming eRNA medicines with scaled data
2:30pm - 3:00pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
New Purification Techniques for Oligonucleotides
2:30pm - 3:00pm30 mins
Peptide Discovery to CMC
A Platform for the Intracellular Generation and High-throughput Screening of Cyclic Peptide Libraries
2:30pm - 3:00pm30 mins
mRNA Technology and Applications
Delivery of RNA Gene Writers in vivo using Lipid Nanoparticles for Correction of Sickle Cell Mutation in HSCs and generation of CAR-T Cells.
2:30pm - 3:00pm30 mins
Delivery of Macromolecules
Delivery of RNA Therapeutics: The Great Endosomal Escape!
3:00pm - 3:30pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
tRNA at the Frontier: Developing Medicines to Treat Stop Codon Disease
3:00pm - 3:30pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Purification Scale up: A Case Study of Volume-Based Scale-Up Approaches in Oligonucleotide Chromatography
3:00pm - 3:30pm30 mins
Peptide Discovery to CMC
Cell Penetrating Properties of Cyclotides and Their Applications for Intracellular Targets
3:00pm - 3:30pm30 mins
mRNA Technology and Applications
Translation of an Optimized Self-replicating RNA Platform with an Expanded Clinical Therapeutic Index
3:00pm - 3:30pm30 mins
Delivery of Macromolecules
A Versatile LNP Platform for in vivo Delivery of mRNA to Cells
Networking Refreshment Break in Poster and Exhibit Hall
3:30pm - 4:15pm45 mins
Networking Refreshment Break in Poster and Exhibit Hall
Networking Refreshment Break in Poster and Exhibit Hall
3:40pm - 3:50pm10 mins
TIDES Talks in Poster and Exhibit Hall
Overcoming Impurities in Therapeutic APIs: Transforming Reagent Solutions for Solid and Liquid Phase TIDES Synthesis
3:50pm - 4:00pm10 mins
TIDES Talks in Poster and Exhibit Hall
A Strategy to Develop Potential and Safe mRNA-based Therapeutics
4:00pm - 4:10pm10 mins
TIDES Talks in Poster and Exhibit Hall
Synthetic Peptide CMC Development and Experiences
4:15pm - 4:45pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
sa-mRNA's Structure and Manufacturing Process Affect Its Final Structure and Functionality
4:15pm - 4:45pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Oligonucleotide Process Development for Scale-Up Manufacturing: Challenges, Strategies, and Future Directions
4:15pm - 4:45pm30 mins
Peptide Discovery to CMC
Engineering Approaches for Improving Stability and Potency of Peptide-based Drug Leads
4:15pm - 4:45pm30 mins
mRNA Technology and Applications
BioNTech’s Individualized Neoantigen Specific Immunotherapies Against Cancer: Concept and Clinical Update
4:15pm - 4:45pm30 mins
Delivery of Macromolecules
Mirai Bio's ML-driven Delivery Platform Provides Fully Integrated, End-to-end Genetic Medicine Development Capabilities for the Biotech Industry
4:45pm - 5:15pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
RNA Technologies That Drive CRISPR-Cas9 Editing
4:45pm - 5:15pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Process development and scale-up for a peptide-conjugated siRNA
4:45pm - 5:15pm30 mins
Peptide Discovery to CMC
“Better-for-You”, Bioactive Peptides for Food
4:45pm - 5:15pm30 mins
mRNA Technology and Applications
mRNA Program for Rare Diseases
4:45pm - 5:15pm30 mins
Delivery of Macromolecules
In vivo Reversible Programming of T cells with SAIL’s Targeted NPs Encapsulating eRNA-encoded CAR for the Treatment of Autoimmune Diseases and Beyond
5:15pm - 5:45pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
In Vivo CRISPR Editing of Genetic Regulatory Regions Results in Functional Upregulation of Target Protein and Reduction of Disease-Associated Biomarker
5:15pm - 5:45pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Regulatory Guideline Development for Oligonucleotides
5:15pm - 5:45pm30 mins
Peptide Discovery to CMC
The Infinite Loop: ML for Discovery, Delivery, and Rapid Manufacturing of Potential Medicines
5:15pm - 5:45pm30 mins
mRNA Technology and Applications
RNA Modifications and Process Enhancements Significantly Improve the Potency of RNA Constructs in Preclinical Testing
5:15pm - 5:45pm30 mins
Delivery of Macromolecules
RNA Delivery Based on a New Class of Synthetic Cationic Materials
5:45pm - 6:45pm60 mins
Networking Reception in Poster and Exhibit Hall
* 活动内容有可能不事先告知作更动及调整。